|
|||||
|
|
| 流式细胞术测定感染旋毛虫小鼠免疫功能的研究 | |
| 引用本文： | 申丽洁,罗志勇,朱声华.流式细胞术测定感染旋毛虫小鼠免疫功能的研究[J].中国病原生物学杂志,2001,14(2):112-113. |
| 作者姓名： | 申丽洁 罗志勇 朱声华 |
| 作者单位： | 1. 大理医学院寄生虫学教研室 2. 大理医学院医学系 3. 华西医科大学寄生虫学教研室 |
| 摘 要： | 目的观察感染旋毛虫小鼠免疫功能的动态变化.方法采用流式细胞术分别检测感染旋毛虫后7、14、21、28、35d小鼠外周血CD4+、CD8+T淋巴细胞的百分率.结果实验组较正常组CD4+T细胞减少,CD8+T细胞增多,CD4+/CD8+细胞比值下降(P＜0.05),以感染后第14d最明显,直到感染后35d仍未见恢复.结论感染旋毛虫的小鼠出现免疫抑制现象,感染急性期的免疫抑制程度最高. |
| 关 键 词： | 流式细胞术 毛线虫 旋 T淋巴细胞 免疫抑制 |
| 文章编号： | 1001-6627(2001)02-0112-02 |
| 修稿时间： | 2000年3月27日 |
STUDY ON THE IMMUNE FUNCTION DETECTION OF MICEINFECTED WITH TRICHINELLA SPIRALIA BY FLOW CYTOMETRY |
|
| SHEN Li-jie,LUO Zhi-yong,ZHU Sheng-hua.STUDY ON THE IMMUNE FUNCTION DETECTION OF MICEINFECTED WITH TRICHINELLA SPIRALIA BY FLOW CYTOMETRY[J].Journal of Pathogen Biology,2001,14(2):112-113. | |
| Authors: | SHEN Li-jie LUO Zhi-yong ZHU Sheng-hua |
| Abstract: | Objective To observe the dynamic changes of T lymphocyte subsets in mice infected with Trichinella spiralis. Methods The percentage of CD 4 and CD 8 T cells were examined by flow cytometry on 7,14,21,28,35 days after mice infected with T. spiralis respectively. Results In experimental group, CD 4 T cells decreased, CD 8 T cells increased, the ratio of CD 4 /CD 8 cells decreased and which was the obvious on the 14th days comparing with normal group (P<0.05). Conclusion The immune function of mice infected with T. spiralis was inhibited, and the degree of immune inhibition was the highest in the acute phase. |
| Keywords: | Flow cytometry Trichinella spiralis T lymphocyte immune inhibition |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |