| 错配修复基因hMSH6及与肿瘤关系的研究进展 |
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| 引用本文： | 宋玉芳,赵亚双.错配修复基因hMSH6及与肿瘤关系的研究进展[J].陕西肿瘤医学,2007,15(9):1336-1339. |
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| 作者姓名： | 宋玉芳 赵亚双 |
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| 作者单位： | 哈尔滨医科大学公共卫生学院流行病学研究室,黑龙江哈尔滨150086 |
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| 基金项目： | 国家自然科学基金资助项目（项目编号：30371243） |
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| 摘 要： | hMSH6是一种错配修复基因,1995年首次发现其参与构成错配结合因子,MSH6是MutS同源物,其作用机制与癌基因及抑癌基因不同,主要影响人类基因组的稳定性。hMSH6基因的突变多为碱基小片段突变,其突变与大肠癌、子宫内膜癌、卵巢癌等的发生相关。人们对该基因的研究日趋完善,本文综述了国外hMSH6基因的作用机制、与肿瘤的关系、测定方法等方面的研究情况。
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| 关 键 词： | hMSH6 肿瘤 突变 |
| 文章编号： | 1672-4992-（2007）09-1336-04 |
| 收稿时间： | 2006-11-13 |
| 修稿时间： | 2006-12-11 |
Advances of hMSH6 gene and cancer |
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| SONG Yu - fang , ZHAO Ya - shuang.Advances of hMSH6 gene and cancer[J].Shaanxi Oncology Medicine,2007,15(9):1336-1339. |
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| Authors: | SONG Yu - fang ZHAO Ya - shuang |
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| Abstract: | It was found that hMSH6 takes part in constituting misparing combining gene, hMSH6 is a mismatch repair gene, which mutations are related to cancers, such as colorectal cancer, endometrial cancer and ovarian cancer. MSH6, the homologue of MutS, its mechanism of action is different from carcinoma gene or restraining gene of carcinoma. Under the influence of MMR gene, the mankind genome stability will change. The most common mutation of MMR gene is small deletions/insertion, the research on this gene has been achieved perfection. This article summarizes the researches abroad on hMSH6 gene, such as the mechanism of action, relation of cancer and test methods. |
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| Keywords: | hMSH6 tumor mutation |
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