Inhibitory action of the ventral noradrenergic bundle on the lateral hypothalamic neurons through alpha-noradrenergic mechanisms in the rat |
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Authors: | Satoshi Miyahara Yutaka Oomura |
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Affiliation: | Unite´de Recherches de Neurophysiologie Pharmacologique de l''INSERM (U. 161), 2 rue d''Ale´sia, 75014 Paris France |
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Abstract: | Electrical stimulation of the ventral noradrenergic bundle (V-NA bundle) produced 3 types of responses in lateral hypothalamic neurons: IPSPs, a polysynaptic EPSP-IPSP sequence and antidromic spikes. The IPSPs were considered to be monosynaptic due to the fixed latencies seen at stimulus intensities. Iontophoretic application of an alpha-NA antagonist blocked only the presumed monosynaptic inhibition. Most of the glucose-sensitive neurons were inhibited by stimulation of the V-NA bundle. These results may account for the hyperphagia and obesity produced by selective lesions of the V-NA bundle. |
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Keywords: | ventral noradrenergic bundle lateral hypothalamic area glucose-sensitive neuron monosynaptic inhibition α -adrenoreceptor feeding suppression |
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