阻塞性睡眠呼吸暂停低通气综合征患者鼻阻力变化及意义

目的：探讨阻塞性呼吸睡眠暂停低通气综合征（ OSAHS）与鼻阻力的相关性。方法收集阻塞性睡眠呼吸暂停低通气综合征（ OSAHS）患者30例（ OSAHS组）、30例打鼾但不伴OSAHS者30例（鼾症组）及正常组30例进行多导睡眠检测的基础上行鼻阻力的检测。结果 OSAS组和鼾症组鼾声指数（42．7±27.3）、（19．4±18．5），夜间睡眠呼吸紊乱指数（AHI）（38．7±30．2）、（5．9±1．6），左右侧鼻阻力（Resl＋r）（1.63±1.11）Pa· s^-1· mL^-1、（0．72±0．31）Pa· s^-1· mL^-1，明显高于正常组（t＝6．451、7．444、7．698，均P＜0.05）；最低血氧饱和度（SaO2）、左右侧鼻气流（Fowl＋r）明显低于正常组（t＝7．551、7．334，均P＜0．05）；鼻阻力与鼾声指数呈明显的正相关（r＝5．658，P＜0．01）；鼻阻力与AHI指数（r＝0．002，P＞0．05），与醒觉次数（r＝0．083，P＞0．05），与最低SaO2均无明显相关（r＝0．105，P＞0．05）；OSAS患者X线头影测量结果提示，多数鼾症或OSAS患者其症状在仰卧位明显。结论 OSAHS患者的鼻阻力增加，可能与OSAHS的发生有关。

Changes of Nasal resistance in obstructive sleep apneasyndrome

Objective To investigate the obstructive sleep apnea syndrome （ OSAHS） associated with nasal resistance.Methods 30 cases with obstructive sleep apneahypopnea syndrome （ OSAHS ） in the OSAHS group, 30 cases with snoring but without OSAHS in the snoring group and 30 cases with normal group based on polysomnog-raphy were detected the nasal resistance.Results The index of thsnoring index（42.7 ±27.3）,（19.4 ±18.5）, AHI（38.7 ±30.2）,（5.9 ±1.6）and Resl＋r（1.63 ±1.11）Pa· s^-1· mL^-1,（0.72 ±0.31）Pa· s^-1· mL^-1] in OSAS group and snoring group were significantly higher than those of the normal group （ t=6.451,7.444,7.698,all P〈0.05）;The index of lowest oxygen saturation （ SaO2 ） ,Flowl＋r in OSAS group and thsnoring group were lower than that in normal group（t=7.551,7.334,all P〈0.05）;There were significant differences among groups of nasal resistance （t=7.451,8.144,8.608,8.904,all P〈0.05）;There were positive correlation between nasal resistance and snore index （r=5.658,P〈0.01）;The index of nasal resistance correlated with AHI index （r=0.002,P〉0.05）,wake times （r=0.083,P〉0.05） and lowest SaO2（r=0.105,P〉0.05）were not significantly correlated;The cases with OSAS cephalometric.The results suggest majority snoring symptoms significantly more at supine posi-tion in OSAS.Conclusion Nasal resistance increased,which may be associated with the occurrence in patients with OSAHS.