调强放疗和常规放疗联合化疗中晚期鼻咽癌的疗效比较

目的观察调强放疗和常规放疗联合化疗对晚期鼻咽癌的疗效及不良反应。方法将Ⅱ~Ⅳ期鼻咽癌患者分为调强放疗组(46例)和常规放疗联合化疗组(50例),制定调强放疗和常规放疗联合化疗方案。分析比较2组患者的疗效和不良反应。结果调强放疗组的完全缓解率和总缓解率较常规放疗联合化疗组均显著提高;远期疗效无明显差异;调强放疗组的皮肤、口干(腮腺)、口腔黏膜反应明显少于常规放疗联合化疗组,白细胞减少发生率、贫血发生率、肝肾功损害率也明显低于常规放疗联合化疗组。结论使用调强放疗可以明显提高晚期鼻咽癌患者的疗效,降低常规放疗联合化疗引起的不良反应。

Comparison of the efficacy of IMRT and conventional radiation therapy combined with chemotherapy in ad-vanced nasopharyngeal carcinoma

Objective To observe the curative effect and adverse reactions of IMRT and conventional radiotherapy combined with chem-otherapy in treating patients with advanced nasopharyngeal carcinoma. Methods The patients were divided into the IMRT group （46 cases） and conventional radiotherapy combined with chemotherapy group （ 50 cases ） . Making the IMRT and conventional radiotherapy combined with chemotherapy treatment plan, and analyze the curative effect and adverse reaction of the two groups. Results Compared with the con-ventional radiotherapy combined with chemotherapy group, IMRT group has a significantly increase in complete remission rate and overall re-sponse rate, but there is no significant difference in long-term efficacy. The skin, dry mouth （ parotid） ,and oral mucositis response is lower in IMRT group, and the neutropenia incidence, prevalence of anemia, liver and kidney function damage rate is also significantly lower than conventional radiotherapy combined with chemotherapy. Conclusion The IMRT can significantly improve the curative effect in treatment of advanced nasopharyngeal carcinoma and reduce the adverse reactions compared with the conventional radiotherapy combined with chemotherapy.