维胺酯胶囊治疗脂溢性皮炎安全性及可行性分析

目的：探讨维胺酯胶囊治疗脂溢性皮炎及可行性分析安全性。方法根据数字表法将84例脂溢性皮炎患者随机分为观察组和对照组，各42例，对照组患者给予1％吡美莫司乳膏外涂，2次/d；观察组在对照组基础上口服维胺酯胶囊50 mg/次，2次/d，2周为1个疗程，连续用药2个疗程。观察两组患者疗效和不良反应。结果观察组治疗4周、8周后红斑、鳞屑、皮脂溢、瘙痒等症状积分及总积分显著低于对照组（红斑t＝5．865、5．786，鳞屑t＝6．112、5．886，皮脂溢t＝5．963、5．629，瘙痒t＝6．123、6．072，均P＜0．05）。观察组治疗1周、4周、8周总有效率分别为57．14％、85．71％、95．24％，对照组分别为42．86％、59．52％、80.95％，差异均有统计学意义（χ2＝5．632、6．986、5．252，均P＜0．05）。观察组复发率为2．38％，低于对照组的19．05％；满意率100．00％，高于对照组的76．19％，差异均有统计学意义（χ2＝5．986、6．123，均P＜0．05）。而两组不良反应发生率差异无统计学意义（χ2＝0．589，P＞0．05）。结论维胺酯胶囊能在较短的时间内改善脂溢性皮炎患者临床症状，效果显著，复发率低，安全有效。

The safety and feasibility analysis of viaminate capsule in the treatment of seborrheic dermatitis

Objective To investigate the safety and feasibility of viaminate capsule in the treatment of sebor-rheic dermatitis.Methods According to the digital table, 84 patients with seborrheic dermatitis were randomly divided into the observation group（n=42） and the control group（n=42）.The control group were treated with 1%pimecrolimus cream coated, 2 times/d.The observation group were treated with capsule viaminate, 50mg/times, 2 times/d,2 weeks for a course of treatment.The clinical efficacy of the two groups were observed.Results The ery thema,scaling,seborrhea,itching and other symptoms score and total score after treatment to 4 weeks,8 weeks of the two groups were compared（Erythema t=5.865,5.786;scaly t=6.112,5.886;seborrhea t=5.963,5.629;itching t=6.123,6.072.all P〈0.05）.The total effective rate of treatment 1 week,4 weeks,8 weeks of observation group were 57.14%,85.71%,95.24%.The control group were 42.86%,59.52%,80.95%,the difference was statistical-ly significant（χ2 =5.632,6.986,5.252,all P 〈0.05）.The patients relapse rate of the observation group was 2.38%,which was lower than 19.05%of the control group（χ2 =5.986,P〈0.05）,and the satisfaction rate of the observation group was 100.00%,which was higher than 76.19%of the control group（χ2 =6.123,P〈0.05）,but the adverse effects of the two groups had no statistically significant（χ2 =0.589,P〉0.05）.Conclusion Viaminate cap-sule can improve in a short period of time in patients with clinical symptoms of seborrheic dermatitis,the effect is sig-nificant,the recurrence rate is low,safe and effective.