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Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria |
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| Authors: | Newton Paul N Chaulet Jean-François Brockman Alan Chierakul Wirongrong Dondorp Arjen Ruangveerayuth Ronatrai Looareesuwan Sornchai Mounier Cyril White Nicholas J |
| Affiliation: | Mae Sot, Tak and Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. |
| Abstract: | The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal. |
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