| 肾小球足细胞内的蛋白质降解机制 |
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| 引用本文： | 曹璐,毛建华.肾小球足细胞内的蛋白质降解机制[J].实用儿科临床杂志,2011,26(17):1367-1370. |
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| 作者姓名： | 曹璐 毛建华 |
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| 作者单位： | 浙江大学医学院附属儿童医院,肾内科,杭州,310006 |
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| 基金项目： | 国家自然科学基金(81070561,30971365); 卫生部科学研究基金-浙江省医药卫生重大科技计划(WKJ2010-2-014); 浙江省卫生高层次创新人才培养对象及浙江大学基本科研业务费专项资金-青年科研创新专项经费(5A7000*172210101/31) |
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| 摘 要： | 足细胞在维系肾小球滤过屏障的选择通透性方面有重要作用,而足细胞损伤导致的蛋白尿则足肾小球疾病的重要标志足细胞胞质内中主要有2种蛋白降解途径:自噬系统和泛索蛋白酶体系统.了解蛋白降解机制变化对足细胞的影响,期望为今后肾脏疾病的治疗提供可靠依据.
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| 关 键 词： | 足细胞 蛋白降解 自噬 泛素蛋白酶系统 |
Mechanism of Protein Degradation in Glomerular Podocytes |
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| CAO Lu
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MAO Jian-hua.Mechanism of Protein Degradation in Glomerular Podocytes[J].Journal of Applied Clinical Pediatrics,2011,26(17):1367-1370. |
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| Authors: | CAO Lu MAO Jian-hua |
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| Institution: | (Department of Nephrology,the Children′s Hospital of Zhejiang University School of Medicine,Hangzhou 310006,Zhejiang Province,China) |
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| Abstract: | Podocytes play a crucial role in establishing the selective permeability of the blood-urine filtration barrier.Dysfunctions of podocytes lead to proteinuria which is a hallmark of most glomerular diseases.There are 2 kinds of protein degradation pathways in podocyte cytoplasm:autophagy system and the ubiquitin proteasome system.It will help us to understand the key role of podocytes playing in integrity of glomerular filtration barrier by studying the mechanism of the intracellular protein degradation,which... |
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| Keywords: | podocytes protein degradation autophagy ubiquitin-proteasome system |
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