| 胰岛素样生长因子-1受体基因与特发性矮小相关性研究进展 |
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| 引用本文： | 黄慧,杨玉.胰岛素样生长因子-1受体基因与特发性矮小相关性研究进展[J].实用儿科临床杂志,2011,26(20):1602-1604. |
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| 作者姓名： | 黄慧 杨玉 |
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| 作者单位： | 江西省儿童医院内分泌科,南昌,330006 |
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| 摘 要： | 生长激素-胰岛素样生长因子(GH-IGF)轴是调节儿童生长发育中最重要的神经内分泌轴.胰岛素样生长因子-1受体( IGF-1 R)是调节该轴的激素受体级联反应的效应分子,它的分子结构或功能异常,将影响靶基因IGF-1与其结合,从而引起生长障碍,可能与特发性矮小(ISS)发生有一定关系.国内外尚无IGF-1R基因与ISS的研究,为探讨其与ISS的关系,现就近年来有关IGF-1 R与人体生长障碍的研究作简要综述.
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| 关 键 词： | 特发性矮小 胰岛素样生长因子-1受体基因 胰岛素样生长因子-1 |
Progress on Research of Association of Insulin-Like Growth Factor-1 Receptor Gene with Idiopathic Short Stature |
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| HUANG Hui
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YANG Yu.Progress on Research of Association of Insulin-Like Growth Factor-1 Receptor Gene with Idiopathic Short Stature[J].Journal of Applied Clinical Pediatrics,2011,26(20):1602-1604. |
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| Authors: | HUANG Hui YANG Yu |
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| Institution: | (Department of Endocrinology,Jiangxi Children′s Hospital,Nanchang 330006,Jiangxi Province,China) |
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| Abstract: | Growth hormone-insulin-like growth factor axis is the most essential neuroendocrine axis for children growth and development.Insulin-like growth factor-1 receptor(IGF-1R) is an effector molecule that adjusts the cascade of hormone receptor response.The abnormality in its molecular structure or function will affect its binding with target gene IGF-1,which leads to growth retardation.This may be related to the occurrence of idiopathic short stature.Abroad there was no gene for IGF-1R study of the relationship... |
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| Keywords: | idiopathic short stature insulin-like growth factor-1 receptor gene insulin-like growth factor-1 |
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