| 电针改善血管性痴呆大鼠学习记忆及其与海马神经细胞谷氨酸、NMDAR表达的关系 |
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| 引用本文： | 韦登明,贾学敏,尹向旭,蒋雯雯. 电针改善血管性痴呆大鼠学习记忆及其与海马神经细胞谷氨酸、NMDAR表达的关系[J]. 中国老年学杂志, 2011, 31(19) |
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| 作者姓名： | 韦登明 贾学敏 尹向旭 蒋雯雯 |
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| 作者单位： | 宁波大学医学院病理教研室,浙江 宁波,315211 |
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| 基金项目： | 浙江省自然科学基金，宁波市科技局自然科学基金 |
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| 摘 要： | 目的 观察电针对血管性痴呆(VD)大鼠学习记忆功能和海马谷氨酸及其NMDA受体表达的影响,探讨电针的治疗作用机制.方法SD大鼠,随机分为正常对照组、假手术组、模型组、电针组.在建立VD大鼠模型后,电针“百会”、“大椎”穴,水迷宫观察大鼠学习记忆能力,免疫组织化学染色技术观察脑组织海马谷氨酸及其NMDA受体染色结果.结果 与模型组比较,经电针治疗后水迷宫潜伏期明显缩短(P＜0.01),相同时间内在原平台象限跨越相应平台次数明显增多(P＜0.01)；谷氨酸及其NMDA受体免疫阳性细胞积分光密度显著增加(P＜0.01).结论 电针大鼠“白会”、“大椎”穴能改善大鼠学习记忆能力,其机制可能与提高海马谷氨酸及其NMDA受体表达有关.
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| 关 键 词： | 血管性痴呆 电针 学习记忆能力 谷氨酸 NMDA受体 |
Effects of electroacupuncture on learning and memory ability and expression of glutamate (Glu) and N-methyl-D-aspartate receptor (NMDAR) in hippocampal of vascular dementia rats |
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| WEI Deng-Ming,JIA Xue-Min,YIN Xiang-Xu,et al.. Effects of electroacupuncture on learning and memory ability and expression of glutamate (Glu) and N-methyl-D-aspartate receptor (NMDAR) in hippocampal of vascular dementia rats[J]. Chinese Journal of Gerontology, 2011, 31(19) |
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| Authors: | WEI Deng-Ming JIA Xue-Min YIN Xiang-Xu et al. |
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| Affiliation: | WEI Deng-Ming,JIA Xue-Min,YIN Xiang-Xu,et al. Department of Pathology of Medical School of Ningbo University,Ningbo 315211,Zhejiang,China |
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| Abstract: | Objective To observe the effect of electroacupuncture(EA) on spatial learning and memory ability,hippocampal glutamate(Glu) and N-methyl-D-aspartate receptor(NMDAR) expression in rats with vascular dementia(VD),and explore its underlying mechanism in improving VD.Methods SD rats were randomly divided into control,sham-operation,model,EA groups.Rat model of VD was established by repeated ischemia/reperfusion and pretreated with sodium nitroprusside.EA was applied to Baihui(GV20),Dazhui(DU14) in EA group for ... |
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| Keywords: | Vascular dementia Electroacupuncture Learning and memory ability Glutamate(Glu) N-methyl-D-aspartate receptor(NMDAR) |
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