| 淋巴结微转移检测对大肠癌病理分期的影响 |
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| 引用本文： | 于游,张才全.淋巴结微转移检测对大肠癌病理分期的影响[J].中国老年学杂志,2011,31(21). |
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| 作者姓名： | 于游 张才全 |
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| 作者单位： | 重庆医科大学附属第一医院胃肠外科,重庆,400016 |
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| 摘 要： | 目的 研究淋巴结微转移对结肠癌患者病理分期的影响.方法 对1120枚结直肠癌患者淋巴结进行常规HE染色和CK20、CEA免疫组化微转移的检测,并对结果进行统计学分析.结果 CK20检测出有微转移淋巴结103枚,占9.2％(103/1120),CEA检测出有微转移淋巴结88枚,占7.9％ (88/1120).CK20联合CEA检测出130枚淋巴结检出有微转移,占11.6％ (130/1120).肿瘤浸润愈深,微转移愈易发生(P＜0.05),分化程度低者,微转移阳性率高(P＜0.05).130枚淋巴结检出有微转移,13例TNM分期提高,其中Ⅰ期→Ⅲ期2例,Ⅱ期→Ⅲ期11例,HE染色重新分期率为18.6％ (13/70).结论 结直肠癌淋巴结免疫组化检测有助于更准确地进行结直肠癌的临床病理分期.
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| 关 键 词： | 结直肠肿瘤 微转移 免疫组化 肿瘤分期 |
Impact of lymph node micrometastasis detection on pathological staging of colorectal carcinoma |
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| YU You,ZHANG Cai-Quan.Impact of lymph node micrometastasis detection on pathological staging of colorectal carcinoma[J].Chinese Journal of Gerontology,2011,31(21). |
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| Authors: | YU You ZHANG Cai-Quan |
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| Institution: | YU You,ZHANG Cai-Quan.Department of Gastrointestinal Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | Objective To detect the rate of micrometastasis in regional lymph nodes and evaluate the significance of lymph node micrometastasis in determining PTNM staging in colorectal carcinoma.Methods In addition HE,immunohistochemical(IHC) for Cytokeratin-20(CK20) and CEA were used to detect micrometastasis in 1 120 lymph nodes from 70 patients with colorectal carcinoma.Results In 1 120 regional lymph nodes,9.2%(103/1 120) were positive for metastasis by CK20,7.9%(88/1120) by CEA and 11.6%(130/1120) by combined IHC... |
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| Keywords: | Colorectal carcinoma Micrometastasis IHC Neoplasma staging |
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