Surgery as a Bridge to Palliative Chemotherapy in Patients with Malignant Bowel Obstruction from Colorectal Cancer |
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Authors: | Lucy K Helyer Calvin H L Law Mathew Butler Linda D Last Andrew J Smith Frances C Wright |
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Institution: | (1) Department of Surgical Oncology, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, 2075 Bayview Ave., Room T2-063, Toronto, ON, M4N 3M5, Canada;(2) Department of Surgery, University of Alberta, Alberta, Canada |
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Abstract: | Background Malignant bowel obstruction (MBO) is a feature of the clinical course of 10–28% of colorectal cancer (CRC) patients and is
associated with a poor prognosis. Recent advancements in palliative chemotherapy regimens have prolonged survival in patients
with stage IV CRC. Few reports exist that describe outcomes in patients who have had surgery for MBO and subsequent chemotherapy
as part of their treatment. The objective of this study was to review surgical outcomes in patients with MBO for CRC and to
evaluate the extent to which surgery can serve as a bridge to palliative chemotherapy.
Methods Patients who presented with MBO and had surgical treatment were identified from a prospectively kept database at a single
tertiary care center between 09/99 and 08/04. Charts were retrospectively reviewed and clinical and outcomes data were abstracted.
Results Forty-seven patients were identified who had surgery as part of the treatment for MBO from CRC. Operations included resections,
bypasses and stoma creation. Overall, 80% of patients were able to tolerate solid food post-operatively and return home. The
median survival for the entire cohort was 3.5 months. Seven patients died within 30 days of surgery. Of the remainder, 24
patients were palliated with surgery alone and 16 patients ultimately received palliative chemotherapy. Survival in the final
cohort was significantly prolonged (P < 0.001).
Conclusion Surgery can adequately palliate a substantial proportion of patients with MBO from CRC with acceptable morbidity and mortality.
In addition, in a subset of patients it can facilitate palliative chemotherapy that is associated with improved overall survival.
Dr. Calvin Law is a Career Scientist of the Ontario Ministry of Health and Long Term Care and is supported through a Health
Research Personnel Development—Career Scientist Award. |
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Keywords: | Malignant bowel obstruction Colorectal adenocarcinoma Palliative chemotherapy Survival Surgery |
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