LYMPHOID CELLS MEDIATING TUMOR-SPECIFIC CYTOTOXICITY TO CARCINOMA OF THE URINARY BLADDER : SEPARATION OF THE EFFECTOR POPULATION USING A SURFACE MARKER |
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Authors: | C O'Toole V Stejskal P Perlmann and M Karlsson |
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Institution: | From the Department of Immunology, Wenner-Gren Institute, Norrtullsgatan 16, S-113 45 Stockholm, Sweden |
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Abstract: | Peripheral lymphocytes from patients with urinary bladder carcinoma and controls have been separated on the basis of rosette formation with sheep erythrocytes. The fractions were tested for tumor-specific cytotoxicity. The E rosette-forming cells of purity 90% respond well in PHA-induced cytotoxicity but are totally inactive in the tumor assay. The non-E rosette-forming cells (purity 91%) give enhanced activity in the tumor-specific cytotoxicity as well as in antibody-mediated target cell lysis in a model system. These data support the notion that the effector cells in cell-mediated immunity to carcinoma of the urinary bladder are members of the nonthymus-derived population of peripheral lymphocytes. |
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