多西紫杉醇联合替吉奥胶囊治疗晚期胃癌的近期疗效

目的：探讨多西紫杉醇联合替吉奥胶囊治疗晚期胃癌近期疗效及毒副作用。方法按照随机数字表法，将38例晚期胃癌患者均分为实验组和对照组，对照组患者采用多西紫杉醇、亚叶酸钙联合氟尿嘧啶方案化疗，实验组患者采用多西紫杉醇联合替吉奥胶囊方案化疗，对比2组近期疗效、不良反应发生情况以及可评价肿瘤进展时间。结果实验组患者治疗总有效率显著高于对照组，差异具有显著性（P＜0．05）；两组患者不良反应发生率及严重程度对比，差异无统计学意义（P＞0．05）；两组患者可评价肿瘤进展时间对比，差异无统计学意义（P＞0．05）。结论多西紫杉醇联合替吉奥胶囊治疗晚期胃癌能够有效提高近期疗效，且不会明显增加不良反应，也不会对可评价肿瘤进展时间产生明显影响。

Short-term Efficacy of Docetaxel Combined with Tegafur Gimeracil Oteracil Potassium Capsule for Advanced Gastric Cancer

Objective To explore the clinical efficacy and side effects of docetaxel combined with tegafur gimeracil oter -acil potassium capsule for advanced gastric cancer .Methods 38 cases of patients with advanced gastric cancer were randomly divided into the experiment group and the control group ,the control group were treated by taxol ,calcium folinate and fluorouracil , the experiment group were treated by docetaxel combine with tegafur gimeracil oteracil potassium capsule .Clinical efficacy,side effects,and time to progress were compared .Results The total effective rate in the experiment group were higher than that of the control group(P<0.05);There had no significant difference in the rate of side effects and severity (P>0.05);There had no sig-nificant difference in the time to progress(P>0.05).Conclusion Docetaxel combined with tegafur gimeracil oteracil potassium capsule for advanced gastric cancer can increase short-term efficacy without increase of side effects ,and it has no significant effect on time to progress .