右丙亚胺对接受表柔比星化疗的胃癌患者的心脏保护作用 |
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引用本文: | 谢和民. 右丙亚胺对接受表柔比星化疗的胃癌患者的心脏保护作用[J]. 实用癌症杂志, 2016, 0(4): 622-624. DOI: 10.3969/j.issn.1001-5930.2016.04.031 |
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作者姓名: | 谢和民 |
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作者单位: | 214200,江苏省宜兴市肿瘤医院 |
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摘 要: | 目的 观察右丙亚胺对接受表柔比星(EPI)联合化疗方案的胃癌患者的心脏保护作用.方法 将66例应用含表柔比星方案化疗的患者分成右丙亚胺联合EOX化疗组和EOX化疗组2组,分别采用EOX方案化疗6个周期,以及EOX联合右丙亚胺治疗6个周期,观察2组的心电图变化,并进行比较.结果 在心电图异常发生率方面,右丙亚胺联合EOX化疗组和EOX化疗组分别为12.1%(4/33)和36.4%(12/33),2组差异有统计学意义(P<0.05).EOX化疗组中,出现心电图异常的患者中有12例予以右丙亚胺治疗,经治疗,6例出现心脏损害加重,4例异常心电图保持稳定,2例心电图恢复正常.结论 右丙亚胺对使用表柔比星的胃癌患者的心脏有一定的保护作用,并且对已经形成的损害有一定的治疗作用.
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关 键 词: | 右丙亚胺 表柔比星 胃癌 心脏 |
Cardiac Protective Effect of Dexrazoxane on Patients with Gastric Cancer Patients Treated with Received Epirubicin Chemotherapy |
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Abstract: | Objective To observe the cardiac protective effect of Ddexrazoxane on gastric cancer patients treated with epirubicin chemotherapypatients with gastric cancer received chemotherapy .Methods 66 patients treated with epirubicin chemo-therapycases with epirubicin chemotherapy were divided into dexrazoxane combined with EOX chemotherapy group and EOX chemotherapy group EOX two group ,and were given the EOX regimen for 6 cycles and EOX combined with dexrazoxane for 6 cy-cles and of treatment EOX regimen for 6 cycles,respectively,the changes of ECG of the 2 groups were observed and compared . Results ECG abnormal rate of Dexrazoxane combined with EOX chemotherapy group and EOX chemotherapy group in ECG ab -normal rate were 12.1%(4/33) and 36.4%(12/33), the difference between the two 2 groups hasd statistical significance (P<0.05).In EOX group appeared in ,12 cases of patients with abnormal ECG received dexrazoxane treatment ,after treatment,6 ca-ses of cardiac damage 6 cases of cardiac damage increased ,4 cases of abnormal ECG remained stable , 2 cases of ECG returned to normal after treatment .Conclusion Dexrazoxane has a certain cardiac protective effect on heart of gastric cancer patients treated with epirubicin ,and it has a certain therapeutic effect on heart damage . |
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Keywords: | Dexrazoxane Table soft star Gastric cancer Heart |
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