影响 TACE 治疗原发性肝癌后肝功能损伤的相关因素研究

目的：探讨影响TACE治疗原发性肝癌后患者肝功能损伤的相关因素。方法收集原发性肝癌患者共110例，所有患者经TACE治疗，分析术后患者肝功能损伤发生与性别、年龄、肿瘤大小、TACE前肝功能Child分级、TACE次数、超选择栓塞肿瘤供血支及肝硬化分级的相关性。结果110例原发性肝癌患者TACE术后发生肝功能损伤共19例，未发生肝功能损伤91例；肝功能损伤与患者的性别、年龄、肿瘤直径及Child分级无相关性（ P＞0．05）；与TACE次数和超选择栓塞肿瘤供血支及肝硬化分级呈显著性相关（ P＜0．05）。结论原发性肝癌经TACE术后患者发生肝功能损伤与TACE次数、超选择栓塞肿瘤供血支及肝硬化分级呈显著性相关，术前应严格掌握患者的个体情况，尽量超选择和减少TACE次数，以减少肝功能损伤。

Research of Related Factors of Liver Function Injury in Primary Liver Cancer after TACE

Objective To investigate the related factors of liver function injury in primary liver cancer after TACE . Methods 110 patients with primary liver cancer were treated with TACE ,and correlations between liver function injury and gen-der,age,tumor sizes,child grades before TACE ,times of TACE,selected embolization with tumor blood supply and grades of liver cirrhosis were analyzed .Results There were 19 cases of liver function injury and 91 noninjured cases in all patients .There was no relevance between gender ,age,tumor diameter,child classification and liver function injury (P>0.05).There was significant correlation between selected embolization of tumor blood supply ,times of TACE,grades of liver cirrhosis and liver function injury (P<0.05).Conclusion Liver function injury after TACE in primary liver cancer are significantly correlated with selected em-bolization with tumor blood supply ,times of TACE and liver cirrhosis grades .Before surgery ,individual status of patients should be considered ,and times of TACE should be reduced to decrease liver function injury .