| DNA拓扑异构酶抑制剂在逆转肿瘤多药耐药性中的研究进展 |
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| 引用本文： | 张游华,顾牣赜,牛天力,张青川. DNA拓扑异构酶抑制剂在逆转肿瘤多药耐药性中的研究进展[J]. 现代肿瘤医学, 2016, 0(24): 4030-4033. DOI: 10.3969/j.issn.1672-4992.2016.24.042 |
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| 作者姓名： | 张游华 顾牣赜 牛天力 张青川 |
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| 作者单位： | 上海中医药大学附属普陀医院泌尿外科，上海 200062 |
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| 基金项目： | 上海中医药大学预算内项目(编号2014YSN69) |
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| 摘 要： | DNA拓扑异构酶（DNA topoisomerase，Topo）是细胞凋亡过程中关键的核内酶，Topo抑制剂通过作用于Topo抑制肿瘤的活性。然而在临床中，单独使用一种Topo抑制剂常常引发多药耐药性。研究证明，两种Topo抑制剂联合用药存在协同作用可以逆转这种多药耐药性，但这种联合与药物组配、肿瘤特点和给药顺序密切相关，本文就这种联合用药在逆转肿瘤多药耐药中的研究进展做一综述。
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| 关 键 词： | DNA拓扑异构酶抑制剂 协同作用 多药耐药性 抗肿瘤 |
Research progress on DNA Topoisomerase inhibitors in reversing multidrug resistance of tumor |
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| Zhang Youhua,Gu Renze,Niu Tianli,Zhang Qingchuan. Research progress on DNA Topoisomerase inhibitors in reversing multidrug resistance of tumor[J]. Journal of Modern Oncology, 2016, 0(24): 4030-4033. DOI: 10.3969/j.issn.1672-4992.2016.24.042 |
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| Authors: | Zhang Youhua Gu Renze Niu Tianli Zhang Qingchuan |
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| Affiliation: | Department of Urological Surgery,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China. |
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| Abstract: | DNA topoisomerase(Topo)is a kind of nuclear enzyme,which plays an important role in the process of cell apoptosis. TopoⅠnhibitors act on Topo to inhibit tumor activity. In clinical,however,using TopoⅠnhibitor alone often leads to multidrug resistance. Studies have shown that the synergistic effect which result from combination regi-men of two TopoⅠnhibitors can reverse multidrug resistance,but this kind of combination is related closely to drug proportion,tumor features and delivery schedule. This paper reviews research progress on the drug combination in re-versing multidrug resistance of tumor. |
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| Keywords: | DNA topoisomerase inhibitors synergistic effect multidrug resistant anti - tumor |
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