| 125I-青藤碱大鼠经皮渗透试验研究 |
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| 引用本文： | 张宁,徐莲英,徐培康,钟高仁. 125I-青藤碱大鼠经皮渗透试验研究[J]. 中药材, 2002, 25(6): 412-413 |
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| 作者姓名： | 张宁 徐莲英 徐培康 钟高仁 |
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| 作者单位： | 1. 上海中医药大学,上海200032
2. 复旦大学放射医学研究所,上海200032 |
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| 基金项目： | 上海市教委资助课题(No.99L7) |
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| 摘 要： | 目的:阐明~(125)I-青藤碱经大鼠皮肤给药后渗透和扩散的走向。方法:采用同位素~(125)I-标记青藤碱,涂于大鼠颈部皮肤,在一定时间内测定~(125)I-青藤碱在皮下纵向渗透的深度和横向扩散的范围。结果:~(125)I-青藤碱纵向扩散可达颈椎骨部,横向扩散可达2 cm~2范围,无论是横向还是纵向扩散均呈现出明显的浓度梯度。结论:~(125)-青藤碱不仅可以透皮吸收入血发挥全身作用也可在皮肤表面蓄积发挥局部作用。
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| 关 键 词： | ~(125)I-青藤碱 经皮渗透 |
| 修稿时间： | 2002-01-08 |
Study on the Permeability of 125I-sinomenine via the Transdermai Delivery Way in Rats |
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| Zhang Ning,Xu Lianying,Xu Peikang,Zhong Gaoren. Study on the Permeability of 125I-sinomenine via the Transdermai Delivery Way in Rats[J]. Journal of Chinese medicinal materials, 2002, 25(6): 412-413 |
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| Authors: | Zhang Ning Xu Lianying Xu Peikang Zhong Gaoren |
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| Affiliation: | ShangHai University of Traditional Chinese Medicine, Shanghai 200032. |
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| Abstract: | Objective: To study the permeance and diffusion trend of 125I-sinomenine via the trandermal delivery way in rats. Method:Assay the permeance depth and diffusion area of sinomenine labeled by isotopic 125I in subcutaneous of rats certain time after sinomenine was administrated on the cervical skin of rats. Results: The diffuse of sionmenine can reach cervical spine in longitudinal direction and form an area of 2 cm in transverse direction.The concentration gradient of both directions are significant.Conclusion: 125I-sinomenine can not only be absorbed into blood via the trasdermal delvery way to have whole effect, but also accumulate large amounts in the skin to have a local effect. |
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| Keywords: | 125I-sinomenine Trasdermal delivery |
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