| 新型吲哚胺2,3-二加氧酶抑制剂及其治疗人类疾病的研究 |
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| 引用本文： | 杨云云,李锡帅,杨青. 新型吲哚胺2,3-二加氧酶抑制剂及其治疗人类疾病的研究[J]. 上海医药, 2012, 0(5): 16-19 |
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| 作者姓名： | 杨云云 李锡帅 杨青 |
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| 作者单位： | 复旦大学,上海200433 |
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| 基金项目： | 国家自然基金面上项目（30873153） |
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| 摘 要： | 吲哚胺2,3-二加氧酶（indoleamine2,3-dioxygenase,IDO）是催化色氨酸沿犬尿氨酸代谢途径分解的限速酶,已被证实与肿瘤、阿尔茨海默病、抑郁症和白内障等多种人类疾病的发病机制密切相关。IDO抑制剂是具有新药靶、新机制的广谱药物,应用前景非常广阔。
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| 关 键 词： | 吲哚胺2,3-二加氧酶 吲哚胺2,3-二加氧酶抑制剂 药物发现靶标 肿瘤 阿尔茨海默病 |
Research of the new indoleamine 2,3-dioxygenase inhibitors and its treatment of human diseases |
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| YANG Yun-yun,LI Xi-shuai.YANG Qing. Research of the new indoleamine 2,3-dioxygenase inhibitors and its treatment of human diseases[J]. Shanghai Medical & Pharmaceutical Journal, 2012, 0(5): 16-19 |
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| Authors: | YANG Yun-yun LI Xi-shuai.YANG Qing |
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| Affiliation: | (School of Life Sciences,Fudan University,Shanghai,200433) |
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| Abstract: | Indoleamine 2,3-dioxygenase（IDO） is a monomeric 45 kDa heme-containing dioxygenase that catalyzes the initial and rate limiting step of L-tryptophan（L-Trp） catabolism along the kynurenine pathway（KP）.IDO has been confirmed to have the close relationship of the pathogenesis mechanism with cancer,Alzheimer＇s disease,depression,age-related cataract as well as other diseases characterized by pathological tryptophan metabolism.It is a broad-spectrum agent with the new molecular target and mechanism,which has the promising application prospects. |
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| Keywords: | indoleamine 2 3-dioxygenase inhibitor drug discovery target tumor Alzheimer＇s disease |
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