支气管哮喘患儿血清ECP及IgE水平的测定及其临床意义

目的：探讨血清嗜酸粒细胞阳离子蛋白（ECP）和免疫球蛋白E（IgE）水平在儿童哮喘发病过程中的相关性及意义。方法：实验共对80名哮喘患儿及20名健康儿童血清ECP及IgE进行测定,将实验结果进行统计比较从而得出结论。结果：哮喘患儿发作期血清ECP水平明显高于稳定期、缓解期及健康儿童,三者间比较,差异均具有统计学意义（P〈0.01）;哮喘患儿发作期IgE水平高于缓解期和健康儿童,差异均具有统计学意义（P〈0.01）;但与稳定期比较,差异无统计学意义（P〉0.05）。结论：ECP和IgE都可体现哮喘患儿的发病情况,但相比于IgE,ECP能更好地反映嗜酸性粒细胞的活化状态和气道炎症的发病情况。因此哮喘患儿血清ECP水平可作为诊断哮喘、判断病情发展状况及指导炎症治疗的可靠指标。

Clinical significance of detecting serum levels of ECP and IGE in children with bronchial asthma

Objective： To study the clinical significance of detecting serum levels of ECP and IGE in children with bronchial asthma. Methods： In the study, ECP and IGE of 80 children with asthma and 20 healthy children were detected. Then we compared the data of the experiment results and drew a conclusion. Results.. The ECP level of the children with asthma was significant higher than that in children who were in stable, alleviated and the controlled group （P〈0.01）. The IGE level of the children with asthma was higher than that in children of alleviated and the controlled group （P〈0.01） , but there was no significant difference comparing with children who were in stable group （P〉0.05）. Conclusion.. The level of the ECP and IgE can reflect the status of the asthma children. Compared with IgE, the level of the ECP can reflec progression and inflammation of the disease more clearly. Therefore, serum ECP can be used for diagnosis and judging progression of asthma.