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Cigarette smoking and white matter microstructure
Authors:Matthew?Hudkins,Joseph?O’Neill  author-information"  >  author-information__contact u-icon-before"  >  mailto:joneill@mednet.ucla.edu"   title="  joneill@mednet.ucla.edu"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,Marc?C.?Tobias,George?Bartzokis,Edythe?D.?London
Affiliation:(1) Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences and Biobehavioral Studies, 760 Westwood Plaza #58-227A, Los Angeles, CA 90024-1759, USA;(2) Laboratory of Molecular Neuroimaging, UCLA Semel Institute for Neuroscience and Biobehavioral Studies, Los Angeles, CA, USA;(3) UCLA Brain Research Institute, Los Angeles, CA, USA;(4) Laboratory of Neuroimaging, Department of Neurology, Division of Brain Mapping, UCLA, Los Angeles, CA, USA;(5) Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA;(6) UCLA Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA;
Abstract:

Rationale  

Diffusion tensor imaging has been used before in testing associations between cigarette smoking and white matter integrity, with inconsistent results. Published reports indicate higher fractional anisotropy (FA, a measure of linear water diffusion) in some brain regions and lower FA in others in adult smokers compared to nonsmokers. Adolescent smokers exhibited elevated FA at several brain regions and a positive correlation of FA in the genu corpus callosum with exposure to smoking (pack-years).
Keywords:
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