| HIV-1感染与p21关系的研究进展 |
| |
| 引用本文： | 邱荣元,何生松.HIV-1感染与p21关系的研究进展[J].国际流行病学传染病学杂志,2009,36(2). |
| |
| 作者姓名： | 邱荣元 何生松 |
| |
| 作者单位： | 华中科技大学同济医学院附属协和医院感染科,武汉,430022 |
| |
| 摘 要： | HIV-1的复制及其所致的病理变化与细胞周期紊乱、细胞凋亡密切相关.p21是已知的具有最广泛激酶抑制活性的细胞周期抑制蛋白,它还参与细胞凋亡、老化等.p21成为HIV-1利用宿主生化机制进行复制的关键靶点.此文就近年来p21与HIV-1感染关系的研究进展做了简要综述.
|
| 关 键 词： | 细胞周期 凋亡 |
Relations between p21 and HIV infection |
| |
| QIU Rong-yuan,HE Sheng-song.Relations between p21 and HIV infection[J].International Journal of Epidemiology and Infectious Disease,2009,36(2). |
| |
| Authors: | QIU Rong-yuan HE Sheng-song |
| |
| Abstract: | The life cycle of HIV-1 and the pathological change produced by HIV-1 are associated tightly with the disorders of host cell cycle and apoptosis, p21 is a well-known protein which has wide eyehn-dependent kinase inhibitive activity, and it also involves the process of cell apoptosis and senescence. For this reason, p21 becomes the important target by HIV-1 to complete virus life cycle with the help of host biochemical mechanism. Here the state of its structure and function feature, relations with cell cycle and apoptosis and roles in the HIV-1 infection are reviewed in the article. |
| |
| Keywords: | HW-1 p21 |
| 本文献已被 万方数据 等数据库收录！ |
|
