金石穿胶囊治疗胆石症的临床及实验观察

目的:观察金石穿胶囊(鸡内金,矾石,穿心莲等),治疗胆石症的临床疗效及作用机理.方法:临床病例口服治疗;实验研究以致石饲料诱发豚鼠胆结石,设模型对照及金石穿防治组,于第60天后处死动物,手术取出胆囊观察成石情况,收集血液及胆汁待测,切取部分肝、胆组织留作病检.结果:金石穿临床治愈率40.0%,有效率96.9%,均高于对照组(P＜0.05).动物实验组成石率,胆汁胆固醇(Cho)、总胆红素(BiL)、钙(Ca2 )含量,血清甘油三脂(TG)含量均低于对照组(P＜0.05或P＜0.01).普通光镜及超微结构观察均见对照组肝细胞、胆囊上皮细胞较实验组有显著病理改变.结论:金石穿防治胆石症作用显著.

Clinical and experimental research of Jingshichuan Capsule on curing cholelithiasis

AIM: To observe the curative effect of Jingshichuan Capsule and to try to explore the therapeutic mechanism. METHODS: Medicines were taken orally. During experimental research an animal model of cholelithiasis was established through feeding guinea pig with food which placed a premium on shaping of cholith. The guinea pigs were divided into the pathologic group, the Jingshichuan group and the control group. The animal was executed after sixties days, the gallbladder was taken out by operation to inspect the shaping of cholith; the blood and the bile was collected to be measured; and parts of the tissue of liver and gallbladder were left for pathologic examination. RESULTS: The rate of clinic cure and the rate of effect of Jingshichuan group were separately 40.0% and 96.9%, which was significantly higher than the control group ( P <0.05). The rate of shaping of cholelith, the cholesterol of bile, the total Bil, the content of Ca 2+ , and TG of blood were all obviously lower than the control group ( P <0.05 or P <0.01). The liver cell and the epithelium cell of cholecyst had notably pathological alteration under normal microscope and supermicrostructure check. CONCLUSION: Jingshichuan Capsule can significantly prevent and cure the cholelithiasis.