鼻塞式CPAP治疗新生儿肺炎63例临床分析

目的分析鼻塞式CPAP通气的特点，观察其在早期治疗新生儿肺炎中的临床效果。方法对113例在我院新生儿科住院治疗的新生儿肺炎进行临床疗效观察，所有患儿随机分为两组，治疗组63例常规治疗基础上给予鼻塞式CPAP（采用德国STEPHAN CPAP-A呼吸机），对照组50例给予普通通气（采用鼻导管或头罩吸氧），动态监测两组患儿治疗前、治疗1、8、12h后的动脉血气并进行比较。结果两组患者治疗后12h血气指标间差异有非常显著性意义（P〈0．01）；治疗组病程及机械通气率低于对照组，差异有显著性意义（P〈0．01）。结论鼻塞式CPAP治疗新生儿肺炎，在缩短病程、降低机械通气率等方面明显优越于普通通气，是一种无创、安全、有效的通气方式。

Clinical Analysis of Nosal Continuous Positive Airway Pressure (CPAP) for the Treatment of 63 Newborns with Pneumonia

Objective To analyze the ventilation characteristics of nosal continuous positive airway pressure (CPAP) and to participate in a clinical study on the effect of nosal CACP for the early treatment of newborns with pneumonia.Methods 113 newborns with pneumonia in our hospital were divided into two groups randomly.63 newborns in experimental group were treated with nosal CPAP(STEPHAN CPAP-A,Germany) while 50 newborns in control group were treated with conventional oxygen inhalation method (endotracheal intubation and oxygen inhalation by head set).The two groups were monitored dynamically and blood samples were taken in four times (before treatment and 1h,8h,12h after treatment).Results The blood samples has significant difference in two groups after treatment 12h ;the course and machine ventilation rate of cure group is under vs the control group,there was significant difference in two groups(P<0.01). Conclusion The study shows that nosal CPAP has significant advantages in decreasing the duration of treatment and the invasive duration of ventitalory support in comparison to conventional oxygen inhalation.Nosal CPAP is a non-invasive,safe and effective inhalation method.