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Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates |
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| Authors: | Nijssen S Florijn A Bonten M J M Schmitz F J Verhoef J Fluit A C |
| Institution: | aDepartment of Internal Medicine, Division of Emergency Medicine and Infectious Diseases, F.02.126, University Medical Center Utrecht, P.O. Box 85000, 3508 GA Utrecht, The Netherlands bEijkman-Winkler Institute for Medical Microbiology, University Medical Center Utrecht, The Netherlands cJulius Center for Health Sciences and Patiënt Care, University Medical Center Utrecht, The Netherlands |
| Abstract: | In vitro susceptibility to 15 β-lactam antibiotics was evaluated using Enterobacteriaceae isolated during the SENTRY Antimicrobial Surveillance Program. Piperacillin/tazobactam was the most active penicillin against Escherichia coli, Proteus mirabilis, Klebsiella oxytoca and Klebsiella pneumoniae (94.9%, 98.3%, 87.4% and 82.9% of isolates susceptible). Of the cephalosporins, cefepime was most effective against Escherichia coli, Proteus mirabilis and Enterobacter cloacae (99.2%, 96.3% and 95.2% of isolates susceptible, respectively) and cefoxitin against Klebsiella oxytoca and Klebsiella pneumoniae (98.6% and 95.6% of isolates susceptible). Carbapenems had excellent activity (≥99.5% of all isolates). ESBL-production was confirmed with the ESBL–Etest and disk diffusion test in 1.3% of Escherichia coli isolates, 18.4% of Klebsiella pneumoniae, 12.6% of Klebsiella oxytoca and 5.3% of Proteus mirabilis isolates. |
| Keywords: | SENTRY Beta-lactam antibiotics Enterobacteriaceae Resistance ESBL |
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