| 叶酸偶联白蛋白纳米粒的靶向性及药效评价 |
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| 引用本文： | 刘海,罗晓琴,朱亮,何练芹,洪华云. 叶酸偶联白蛋白纳米粒的靶向性及药效评价[J]. 广东药学院学报, 2007, 23(1): 50-52 |
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| 作者姓名： | 刘海 罗晓琴 朱亮 何练芹 洪华云 |
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| 作者单位： | 南昌大学医学院,药学系,江西,南昌,330006;广东药学院,药科学院,广东,广州,510006 |
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| 基金项目： | 广东药学院校科研和教改项目 |
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| 摘 要： | 目的 考察叶酸偶联白蛋白纳米粒(F-BSANP)的肿瘤靶向性并进行药效评价.方法 采用直接注射法建立小鼠肝癌模型,肝癌小鼠分组进行体内分布及药效实验.结果 包裹钙黄绿素的F-BSANP在肝癌小鼠肝脏中蓄积程度最高;而药效方面,包裹砒霜的F-BSANP组小鼠生存期最长.结论 用叶酸偶联白蛋白纳米粒包裹药物能显著增强药物对肿瘤部位的靶向性,明显提高药效.
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| 关 键 词： | 叶酸 纳米粒 砒霜 靶向性 肝癌 |
| 文章编号： | 1006-8783(2007)01-0050-03 |
| 修稿时间： | 2006-12-31 |
Evaluation of Effect and Targetability on Folate-conjugated Albumin Nanoparticles |
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| LIU Hai,LUO Xiao-Qin,ZHU Liang,HE Liang-Qin,HONG Hua-Yun. Evaluation of Effect and Targetability on Folate-conjugated Albumin Nanoparticles[J]. Academic Journal of Guangdong College of Pharmacy, 2007, 23(1): 50-52 |
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| Authors: | LIU Hai LUO Xiao-Qin ZHU Liang HE Liang-Qin HONG Hua-Yun |
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| Affiliation: | 1. School of Pharmacy, Guangdong College of Pharmacy, Guangzhou, Guangdong 510006, China; 2. Department of Pharmacy, Medical College of Nanchang University, Nanchang, finxi 330006, China |
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| Abstract: | Objective Inspect the effect and targetability on folate -conjugated albumin nanoparticles by animal experiment. Methods Making mouse liver tumor model with immediate injection method. , mice with liver tumor were divided into several groups for experiments of distribution and pharmacodynamics in vivo. Results Calcein level of liver tissue in the group of F-BSANP entrapping calcein was the highest in all groups; The living phase of mouse injected with F-BSANP entrapping arsenic trioxide is the longest. Conclusion F-BSANP entrapping drugs can significantly enhance the drugs to tumor sites and improve their efficacy. |
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| Keywords: | nanoparticles arsenic trioxide targetability liver tumor |
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