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| 盐酸吡格列酮治疗非酒精性脂肪肝的疗效分析 | |
| 引用本文： | 毕婉蓉,张玉臣,许树长.盐酸吡格列酮治疗非酒精性脂肪肝的疗效分析[J].同济大学学报(医学版),2009,30(5):111-114,118. |
| 作者姓名： | 毕婉蓉 张玉臣 许树长 |
| 作者单位： | 1. 同济大学附属同济医院分院消化内科,上海,200092 2. 同济大学附属同济医院分院药剂科,上海,200092 3. 同济大学附属同济医院消化内科,上海,200092 |
| 摘 要： | 目的探讨盐酸吡格列酮（pioglitazone,PIG）治疗非酒精性脂肪肝（non alcoholic fatty liver disease,NAFLD）的疗效。方法168例经B超及CT诊断为NAFLD患者随机分为治疗组（PIG）与对照组（CON）各84例,PIG组予以PIG15 mg/d,早餐前30 min口服,疗程6个月;CON予以维生素E片100 mg/d,疗程6个月。3个月和6个月后比较两组疗效并观察各组血脂、血糖、肝功、胰岛素抵抗指数（homeostasis model assessment of insulin resistance,HOMA-IR）、肝/脾CT值等指标的变化,及NAFLD超声形态学的改善情况。结果相比于CON组,PIG组3个月末体质量指数（bodymass index,BMI）、ALT、GGT下降,肝/脾CT值升高（P〈0.05）,FINS、HOMA-IR下降（P〈0.001）;PIG组6个月末TG、TC、LDL下降（P〈0.05）,BMI、ALT、GGT、FINS、HOMA-IR、CPR下降,肝/脾CT值升高（P〈0.001）。PIG组的总有效率3个月末为46.4%（P〈0.05）、6个月末为95.2%（P〈0.001）。两组在安全性上无差异。结论PIG可有效降低NAFLD患者的血糖、血脂,改善胰岛素抵抗（insulin resistance,IR）,PIG治疗NAFLD安全、有效。 |
| 关 键 词： | 盐酸吡格列酮 非酒精性脂肪肝 胰岛素抵抗 |
Clinical analysis of the efficacy of pioglitazone hydrochloride on the treatment of nonalcoholic fatty liver |
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| Institution: | BI Wan-rong , ZHANG Yu-chen , XU Shu-chang(1. Dept. of Gastroenterology, Branch Hospital of Tongji Hospital, Tongji University, Shanghai 200092, China; 2. Dept. of Pharmacy, Branch Hospital of Tongji Hospital, Tongji University, Shanghai 200092, China; 3. Dept. of Gastroenterology, Tongji Hospital, Tongji University, Shanghai 200092, China) |
| Abstract: | Objective To investigate the curative effects of pioglitazone （PIG） on the with nonalcoholic fatty liver disease （NAFLD）. Methods A total of 168 patients treatment of patients with NAFLD were randomly divided into PIG treatment group and placebo group （CON）, and treated for six months, with 84 cases in each group. Each patient in two groups received separately PIG 15 mg, qd, orally 30 min before breakfast; or vitamin E tablets 100 mg, qd, for six months. Then the curative effects on two groups were compared in the aspects of blood lipid, blood glucose, liver functional tests, homeostasis assessment of insulin resistance （HOMA-IR） , and liver/ spleen CT values. Results （1） As compared with the placebo group, the body mass index （ BMI）, ALT, GGT decreased, liver/ spleen CT value increased significantly （P 〈0.05） ; and FINS, HOMA-IR decreased very significantly （P 〈0. 001 ） in patients of PIG group at the end of three months. （ 2 ） TG, TC, LDL decreased significantly （ P 〈 0.05 ）, while BMI, ALT, GGT, FINS, HOMA-IR, CPR decreased and liver/spleen CT value increased very significantly （P 〈0. 001 ） in the patients of PIG group at the end of six months. （3） The total effective rates were respectively 46.4% （ P 〈 0.05 ） and 95.2 % （ P 〈 0. 001 ） at the end of three months and six months in PIG group. （4） No difference was noted between two groups in safety. Conclusion PIG shows a better efficacy in reduction of the blood glucose, blood lipids and improvement of insulin resistance （IR）. Therefore, PIG is effective and safe in the treatment of NAFLD. |
| Keywords: | pioglitazone hydrochloride nonalcoholic fatty liver disease insulin resistance |
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