Irreversible Amnesia in Rats and Edible Snails under Conditions of Associative Memory Reconsolidation Disturbance Caused by NMDA-Glutamate Receptor Antagonist |
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Authors: | Z I Storozheva S V Solntseva V P Nikitin A T Proshin V V Sherstnev |
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Institution: | P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. |
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Abstract: | The effect of MK-801, an antagonist to NMDA-glutamate receptors, on reconsolidation of olfactory discrimination task in rats
and taste discrimination in edible snails was examined. Twenty-four hours after conditioning, the animals received a single
systemic injection of MK-801 followed by a reminding conditional stimulus. Disturbances in retrieval of the acquired task
were observed 10 days after injection followed by a reminding procedure. Repeated conditioning of these animals did not restore
the task. Injection of MK-801 without reminding stimulation had no effect on task retention. Thus, disturbances of NMDA-dependent
reconsolidation of the associative memory in animals of different taxonomic groups irreversibly eliminated long-term memory. |
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