| 神经干细胞信号转导通路的研究进展 |
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| 引用本文： | 张文贤,王昱军,王小燕,吕江宏. 神经干细胞信号转导通路的研究进展[J]. 中国修复重建外科杂志, 2008, 22(4): 492-495 |
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| 作者姓名： | 张文贤 王昱军 王小燕 吕江宏 |
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| 作者单位： | 甘肃省中医院骨科,兰州,730050 |
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| 摘 要： | 目的对神经干细胞分化发育过程中的基因信号转导途径——Notch信号途径、螺旋．环．螺旋（basichelix-loop-helix，bHLH）转录因子家族信号途径、Wnt信号途径进行综述。方法广泛查阅近年来关于神经干细胞分化发育过程中基因信号转导途径的文献，并进行总结与分析。结果神经系统的生成是多信号转导途径共同作用的结果，其中Wnt信号、bHLH、Notch信号途径之间的复杂选择机制可能存在一个既定的阈值。结论目前，神经干细胞增殖、分化的具体信号转导途径仍不甚清楚。
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| 关 键 词： | 脊髓损伤 神经干细胞 信号转导 神经干细胞增殖 细胞信号转导通路 研究进展 SIGNAL TRANSDUCTION PATHWAY NEURAL STEM CELLS PROGRESS 阈值 存在 选择机制 共同作用 神经系统 结果 分析 文献 方法 因子家族 转录 bHLH helix basic |
| 修稿时间： | 2007-07-12 |
RESEARCH PROGRESS OF NEURAL STEM CELLS SIGNAL TRANSDUCTION PATHWAY |
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| ZHANG Wenxian,WANG Yujun,WANG Xiaoyan,LV Jianghong. RESEARCH PROGRESS OF NEURAL STEM CELLS SIGNAL TRANSDUCTION PATHWAY[J]. Chinese journal of reparative and reconstructive surgery, 2008, 22(4): 492-495 |
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| Authors: | ZHANG Wenxian WANG Yujun WANG Xiaoyan LV Jianghong |
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| Affiliation: | Department of Orthopedics, Traditional Chinese Medicine Hospital, Lanzhou Gansu, 730050, P.R. China. DOCzhangwx@126.com |
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| Abstract: | OBJECTIVE: To summarize Notch, basic helix-loop-helix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells. METHODS: The literature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed. RESULTS: The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the complicated selective system among Notch, bHLH and Wnt gene signal transduction pathways. CONCLUSION: At present, the specific gene signal transduction pathway of multiplication and differentiation of neural stem cells is still unclear. |
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