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Dopamine and methionine-enkephalin in human brain |
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| Authors: | A Ploska H Taquet F Javoy-Agid P Gaspar F Cesselin B Berger M Hamon JC Legrand Y Agid |
| Institution: | 1. Laboratoire de Médecine Expérimentale, CHU Pitié-Salpêtrière, 91, boulevard de l''Hôpital, 75634 Paris Cédex 13, France;2. Laboratoire de Biochimie Médicale, CHU Pitié-Salpêtrière, 91, boulevard de l''Hôpital, 75634 Paris Cédex 13, France;3. INSERM U 154, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 47, boulevard de l''Hôpital, 75651 Paris Cédex 13, France;4. Groupe NB, INSERM U 114, Collège de France, 11, place Marcelin Berthelot, 75231 Paris Cédex 05 France |
| Abstract: | The contents of dopamine (determined radioenzymatically) and methionine-enkephalin (assayed by a radioimmunoassay) were measured in several areas of the human brain. The peptide was principally localized in dopamine-rich structures. In patients with Parkinson's disease, in contrast to the general dopamine deficiency, the reduction in methionine-enkephalin was restricted to the mesencephalon, putamen and lateral pallidum. |
| Keywords: | human brain Parkinson's disease dopamine Met-enkephalin |
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