抗病毒药物耐药被忽视的特点与启示

艾滋病、慢性乙型病毒性肝炎、慢性丙型病毒性肝炎需要长期抗病毒治疗。耐药是长期抗病毒治疗面临的最大问题。在经治患者已经出现抗病毒药物耐药、现有抗病毒药物种类极为有限、多数药物存在交叉耐约的情况下。往抗病毒治疗过程中应充分利用耐药株复制能力下降、毒力较弱、耐药发生有一定时间过程的特点，觇范、及时地进行相关检查及合理调整治疗，最大限度降低耐药所带来的风险和危害。

Inspirations on the neglected characteristics of antiviral resistance

Long-term antiviral therapy is the standard treatment for acquired immune deficiency syndrome, chronic hepatitis B, and chronic hepatitis C. Meanwhile, increasing risk of drug resistance has become the biggest challenge in long-term antiviral therapy. More and more antiviral drug resistances have emerged in treatment experienced patients at present. But there are only a few of limited choices among antiviral agents. Furthermore, the existence of cross-resistance limits the use of the alternative antiviral agents. Under this circumstance, it is important to minimize the risks and hazards of drug resistance by making lull use of the characteristics of drug resistance, such as decreased replication capacity and virulence of drug-resistant strains, testing the mutants and adjusting the treatment regime as soon as possible.