| 青少年高血压与空腹血浆Ghrelin水平及体质指数的关系 |
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| 引用本文： | 刘博伟,李佳芮,刘俊茹,曹晓斌,马春明,陆强,尹福在. 青少年高血压与空腹血浆Ghrelin水平及体质指数的关系[J]. 医学临床研究, 2012, 0(11): 2111-2113 |
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| 作者姓名： | 刘博伟 李佳芮 刘俊茹 曹晓斌 马春明 陆强 尹福在 |
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| 作者单位： | [1]河北医科大学附属秦皇岛市第一医院内分泌科,河北秦皇岛066000 [2]河北省沧州市中心医院内分泌科,河北沧州061000 |
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| 摘 要： | 【目的】探讨青少年高血压与空腹血浆Ghrelin水平及体质指数（BMI）的关系。【方法】选取秦皇岛市13～15岁青少年158名，根据血压分为高血压组（n=48）和血压正常对照组（n=110），测量身高、体质量，计算体质量指数（BMI）。空腹静脉采血，测量空腹血糖、三酰甘油、高密度脂蛋白胆固醇（HDL-C）、真胰岛素和血浆Ghrelin水平。【结果】高血压组BMI、真胰岛素和HOMA-IR水平高于对照组[分别（25．1±4．7）比（21．8±3．9）kg／m2，t=4．474；（2．8±0．5）比（2．6±0．6）IU／L，t=2．184；（1．3±0．6）比（1．1±0．6），t=1．985；均P〈0．053，两组Ghrelin、空腹血糖、三酰甘油和HDL-C水平差异无统计学意义。Ghrelin与收缩压和舒张压无相关。收缩压和舒张压均与BMI（分别r=0．531，0．376；均P〈0．01）、ln（HOMA-IR）（分别r=0．242，0．185；均P〈0．01）、1n（真胰岛素）（分别r=0．243，0．204；均P〈0．01）呈正相关。行多元线性回归显示，BMI是收缩压和舒张压的独立影响因素（分别β=1．759，0．776；均P〈0．01）。【结论】青少年高血压与BMI密切相关。
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| 关 键 词： | 高血压 血液 人体质量指数 青少年 |
Correlation of Hypertension with Fasting Plasma Ghrelin Level and Body Mass Index in Adoles-cents |
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| Affiliation: | LIU Bo-wei, LI Jia-rui, LIU Jun-ru,et al ( Department of Endocrinology, First Hospital of Qinhuangdao City, Hebei 066000, China ) |
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| Abstract: | [Objective] To explore the correlation of hypertension with fasting plasma ghrelin level and body mass index（BMI） in adolescents. [Methods] A total of 158 adolescents aged 13 15 years old in Qin- huangdao city were enrolled. According to blood pressure, all subjects were divided into hypertension group（ n =48） and normotension group（ n = 110）. Height and weight were measured. BMI was calculated. Blood samples were collected. Fasting plasma glucose（FPG）, triglyceride（TG）, high density lipoprotein cholesterin （HDL-C）, true insulin（TI） and plasma ghrelin were assayed. [Results] BMI, TI and insulin resistance index （HOMA-IR） in hypertension group were higher than those in control group[（25.1±4.7） vs （21.8 ± 3.9） kg/ m2,t=4.474;（2.8±0.5） vs （2.6±0.6） IU/ L,t=2.184; （1.3±0.6）vs （1.1±0.6）,t=1.985; respec- tively, all P 〈0.05]. There was no significant difference in ghrelin, FPG, TG and HDL-C. Ghrelin had no relation with systolic pressure（SBP） and diastolic pressure（DBP）. SBP and DBP were positively related with BMI（r=0. 531, 0. 376; respectively, all P 〈0.01）, ln（HOMA-IR）（r=0. 242, 0. 185; respectively, all P〈0.01） and ln（TI）（ r=0. 243,0. 204; respectively, all P 〈0.01）. Multiple linear regression analysis showed BMI was an independent influencing factor of SBP and DBP（13 = 1. 759, 0. 776; respectively, all P 〈 0.01）. [Conclusion] Adolescent hypertension is closely related with BMI. |
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| Keywords: | hypertension/BL body mass index adolescence |
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