936例肺结核患者治疗和预后的影响因素分析

【目的】探讨肺结核患者的治疗方法及预后的影响因素。【方法】回顾性分析本院自2009年1月至2011年12月的936例住院治疗的肺结核患者的临床资料，936例患者采用常规抗结核药物联合丁胺卡那与左氧氟沙星治疗，分析预后的影响因素。【结果】936例肺结核患者治疗的有效率为98．82％（925／936）；单因素分析显示影响预后的因素为治疗前结核患者年龄、结核的分型以及规范治疗（P〈0．05）；COX模型多因素分析显示病变部位与原结合病灶部位的关系、规范化治疗、原发肿瘤的分期情况与患者的预后具有相关性（P＜0．01）。【结论】肺结核患者并发有肺癌的病例容易被漏诊，重视规范化治疗可以降低结核患者复治的比例，注意有恶变危险因素的患者，提高患者的健康质量。

Analysis of the Factors Influencing the Treatment and Prognosis of 936 Patients with PulmonaryTuberculosis

[Objective] To explore the affecting factors of the treatment and prognosis of patients with pul- monary tuberculosis. [Methods] Clinical data of 936 hospitalized patients with pulmonary tuberculosis patients in our hospital from Jan. 2009 to Dec. 2011 were retrospectively analyzed. All 936 patients were treated with conventional anti-tuberculosis drugs ie. amikacin combined with levofloxacin. Univariate analysis of survival a- nalysis was taken with Kaplan-Meier and log-rank rank test. The prognostic factors were analyzed. [Results] The effective rate of 936 patients with pulmonary tuberculosis was 98.82% （925/936）. Univariate analysis showed that the factors affecting the prognosis were the age of tuberculosis patients before treatment, tubercu- losis type and standard therapy（ P 〈0.05）. COX-model multifactor analysis showed the relation between the lesion site and original conjunctive lesion site and the association of regular therapy and primary tumor stage with the prognosis of patients（ P 〈0.01）. [Conclusion] The missed diagnosis of tuberculosis patients compli- cated with lung cancer easily appears. The emphasis on the standardized treatment can reduce the proportion of the retreatment of tuberculosis patients. The patients with the risk factors of deterioration should be paid at- tention, and the health quality of patients should be improved.