高血压合并心脑血管梗死事件患者高敏C反应蛋白与中医证候的相关性研究

目的研究高血压合并心脑血管拴塞事件患者高敏c反应蛋白（HCRP）与中医证候的相关性。方法检测328例原发性高血压患者血清HCRP的浓度，比较心脑血管梗死事件发生与否的HCRP浓度变化和中医证候的特点，分析HCRP与中医证候间的关联。结果高血压合并急性心脑血管事件组患者多伴有HCRP异常增高，中医证候以风证、痰证为主；陈旧事件组HCRP异常率次之，虚证出现率高（P〈0．01）。HCRP升高时患者风证和痰证的发生率显著增加。并且风证和痰证成立组的HCRP浓度分别高于风证和痰证不成立组。Spearman相关分析提示，HCRP浓度与风证、痰证和虚证存在一定正相关关系。结论高血压病患者血清HCRP浓度变化既可以预测心脑血管梗死事件的发生，又与风证、痰证和虚证存在一定相关性。

Correlation between High - sensitivity C - reactive Protein and TCM Syndromes of Hypertensive Patients with Cardiovascular and Cerebrovascular Infarction

Objective To study the correlation between high - sensitivity C - reactive protein （HCRP） and traditional Chinese medicine（TCM） syndromes in hypertensive patients with cardiovascular and cerebrovascular infarct events. Methods The serum concentration of HCRP was detected in 328 patients with essential hypertension. The HCRP concentration changes and TCM syndrome characteristics were compared in the case of the occurrence or non - occurrence of cardiovascular and cerebrovascular infarct events. And the correlation between HCRP and TCM syndromes were analyzed. Results HCRP was increased in most hypertensive patients with acute cardiovascular and cerehrovascular events,and the main TCM syndromes were wind syndrome and phlegm syndrome. The HCRP abnormal rate was the second place and the occurrence of deficiency syndrome was high in the obsolete events group （P% 0.01）. When HCRP abnormally increases, the occurrence of wind syndrome and phlegm syndrome also increased significantly. And compared with non- wind syndrome group or non - phlegm syndrome group, the HCRP concentratiorl in wind syndrome group or phlegm syndrome group was elevated respectively. Spearman correlation analysis showed that there were some positive correlation between HCRP concentration,wind syndrome,phlegm syndrome,and deficiency syndrome. Conclusion Serum HCRP concentration in hypertensive patients could predict the occurrence of cardiovascular and eerebrovascular infarct events. And HCRP was related with some TCM syndromes,such as wind syndrome,phlegm syndrome and deficiency syndrome.