| 原发性高血压患者血清hs-CRP和ET-1、NO检测的意义 |
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| 引用本文： | 张臣,刘翔,邢之华,钟广伟,张丽波,柴晓利.原发性高血压患者血清hs-CRP和ET-1、NO检测的意义[J].医学临床研究,2012(11):2123-2125. |
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| 作者姓名： | 张臣 刘翔 邢之华 钟广伟 张丽波 柴晓利 |
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| 作者单位： | [1]湖南省第二人民医院心血管内科,湖南长沙410007 [2]中南大学湘雅医院中西医结合研究所,湖南长沙410008 |
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| 摘 要： | 【目的】探讨原发性高血压（EH）患者血清超敏C反应蛋白（hs-CRP）和内皮素-1（ET-1）；一氧化氮（N0）变化的临床意义。【方法】对60例EH患者进行血清hs-CRP和ET-1、NO测定，并与健康对照组作比较分析。【结果】与对照组比较，EH组血清hs-CRP、ET-1明显升高，且随高血压分级升高而逐渐升高（P〈0．01）；血浆NO明显降低，且随高血压分级升高而逐渐降低（P〈0．01）。【结论】高血压病与炎症活动及血管内皮功能紊乱有关，血清hs-CRP和ET-1、NO是反映EH患者代谢异常的重要指标，可用于评估其病情的严重程度。
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| 关 键 词： | 高血压 A液 C反应蛋白质 A液 内皮缩血管肽-1 血液 一氧化氮 A液 |
Clinical Significance of the Detection of Serum High Sensitivity C-reactive Protein, Endothelin-1 and Nitric Oxide in Patients with Essential Hypertension |
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| Institution: | ZHANG Chen, LIU Xiang, XING Zhi-hua,et al (Department of Cardiology, Second People＇s Hospital of Hunan Province, Changsha 410007, China ) |
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| Abstract: | Objective] To explore the clinical significance of the changes of serum high sensitivity C-reac- tive protein （ Hs-CRP）, endothelin-1 （ET-1） and nitric oxide （NO） in patients with essential hypertension （EH）. Methods] The levels of serum hs-CRP, ET-1 and NO in 60 EH patients were measured and compared with those of healthy control group. Results] Compared with control group, the levels of serum hs-CRP, ET- 1 and NO in EH group obviously increased, and gradually elevated with the increasing of EH grade（ P 0.01）. The NO level obviously decreased, and reduced with the increasing of EH grade （P〈 0. 01）. Conclusion]Hypertension is related to inflammation and vascular endothelium. Serum hs-CRP, ET-1 and NO are the important indicators of metabolic disorder of EH patients, and can be used to evaluate the severity of the illness in such patients. |
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| Keywords: | hypertension/BL c-reactive protein/BL endothelin-1/BL nitric oxide/BL |
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