降钙素原检测在急性有机磷农药中毒患者病情早期评估中的作用

【目的】探讨降钙素原（PCT）水平与有机磷农药中毒患者病情严重程度的关系。【方法】对45例急性有机磷农药中毒患者进行APACHEⅡ评分并测定其血清PCT水平，按评分的高低不同分为A、B、C三组，比较各组患者的PCT水平和预后；根据预后分为存活组和死亡组，比较两组的APACHEⅡ评分和PCT水平及相关性。【结果】正常对照组PCT水平为（0．074±0．02）μg／L，观察组PCT水平为（4．23±1．05）μg／L，两组间比较差异有显著性（P〈0．05）；A、B、C三组间PCT水平和病死率比较均有显著性（P〈0．05）；死亡组APACHEⅡ评分与PCT水平均显著高于存活组，且差异有显著性（P〈0．05）；患者PCT水平与APACHEII评分呈显著正相关（r=0．65，P〈0．05）。【结论】PCT水平与APACHEⅡ评分有较强的相关性，可应用于急性有机磷农药中毒患者病情严重程度和预后的评估。

Role of Procalcitonin Measurement in the Early Assessment of the Severity of Patients with A-cute Organophosphorus Pesticide

Objective] To explore the relationship between procalcitonin（PCT） level and the severity of patients with organophosphorus pesticide. Methods]APACHE Ⅱ score of 45 patients with organophosphorus pesticide were recorded and serum PCT level was measured. According to the different scores, all patients were divided into group A, group B and group C. PCT level and the prognosis of patients were compared a- mong groups. According to the prognosis, the patients were divided into survival group and death group. A- PACHE Ⅱ score, PCT level and their relationship were compared between these two groups. Results] PCT level of normal control group and observation group were （0.07 ± 0. 02）μg/L and （4.23±1.05）μg/L re- spectively, and there was significant difference between two groups（ P 〈0.05）. There were significant differ- ences in PCT level and the mortality among three groups（ P 〈0.05）. APACHE Ⅱscore and PCT level of death group were significantly higher than those of survival group, and there were significant differences be- tween two groups（ P 〈0.05）. PCT level of patients was significantly positively correlated to APACHE II score（r=0.65, P 〈0.05）. Conclusion] There is a strong correlation between PCT level and APACHE Ⅱscore. PCT level can be applied in the assessment of the severity and prognosis of patients with acute organo- phosphorus pesticide.