鼻咽癌放疗中甘氨双唑钠增敏与顺铂增敏作用的比较

目的:比较甘氨双唑钠(CMNa)与顺铂(DDP)在鼻咽癌放射治疗中的增敏作用和副作用.方法:首程治疗62例鼻咽癌患者,随机分DDP组及CMNa组,用药方法:CMNa每次按800 mg/m2给药,用100 ml生理盐水溶解后,于30 min内静脉滴注,60 min内进行常规放射治疗.每周一、三、五用药,至常规放射治疗结束为止.DDP每次10 mg,用250 ml生理盐水溶解后,第1,第2周,1次/d,第5周重复.照射方法:先制作面模固定,在模拟机下设面颈联合野放疗DT 36 Gy/18次/3.5周,后改设耳前野和鼻前野(或耳后野)放疗总量至DT 68～72 Gy/34～36次/6.5～7周.结果:CMNa增敏作用与DDP增敏作用P＞0.05无明显差异,但CMNa组消化道反应小,对血常规及肝功能影响不明显P＜0.01.结论:CMNa及DDP均具有放射治疗增敏作用,二者无明显差异,而CMNa组副作用更少.但其长期疗效有待进一步研究.

Comparison between DDP and CMNa in nasopharyngeal carcinoma

Objective: To compare DDP and CMNa in radiosensitivity and side-effect in patients with nasopharyngeal carcinoma.Methods: Sixty-two patients were randomized into two groups,DDP group and CMNa group.CMNa was used venously with 800 mg/m2 in 30 minutes and radiotherapy was performed in 60 minutes in Monday,Wednesday and Friday for every week from the beginning to the end of the radiotherapy.DDP was used venously with 10mg daily from Monday to Friday in first two weeks and in the fourth and fifth week.Facial-neck field was given with 38GY,then facial-jugular field and anterior-nasal field were given with 30-34GY. Results: In the two groups the CR PR for local lesion was 93.3% and 84.38% respectively,90.9% and 84.38% respectively for lymph node,and the remote metastasis for the two groups was 16.67% and 18.75%. Conclusion: There was no significant difference in radiosensitivity(P>0.05) in two groups but the side-effect in the DDP group was more severe than in CMNa group,And the long term effect needs further study in the future.