| 黄芪、牛蒡子不同配伍对糖尿病大鼠糖脂代谢及肾脏病变的影响 |
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| 引用本文： | 王巍巍,陈以平.黄芪、牛蒡子不同配伍对糖尿病大鼠糖脂代谢及肾脏病变的影响[J].中国中医药信息杂志,2008,15(9):31-33. |
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| 作者姓名： | 王巍巍 陈以平 |
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| 作者单位： | 1. 中国人民解放军第455医院,上海,200052
2. 上海中医药大学附属龙华医院,上海,200032 |
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| 摘 要： | 目的观察黄芪、牛蒡子不同配伍对糖尿病大鼠糖脂代谢及肾脏病变的影响。方法建立STZ大鼠模型，将黄芪、牛蒡子各分为高、中、低3个给药剂量，按照正交试验设计方法进行不同剂量的组合，大鼠灌胃，第4、8周时检测血糖、血脂、24h尿蛋白定量，并观察肾组织病理学改变。结果黄芪、牛蒡子配伍可降低糖尿病大鼠血糖、血脂，减少24h尿蛋白的排出，抑制系膜基质积聚。实验第4周时，以牛蒡子高剂量为主的配伍，降血糖和胆固醇的作用较好；第8周时，以黄芪高剂量为主的配伍降低三酰甘油、糖化血红蛋白，减少24h尿蛋白及系膜基质的作用显著。结论黄芪、牛蒡子配伍可纠正糖尿病大鼠糖脂代谢紊乱，减轻肾脏病变；在实验不同阶段，黄芪、牛蒡子不同剂量的配伍存在作用差别。
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| 关 键 词： | 黄芪 牛蒡子 正交设计 糖尿病大鼠模型 |
Effects of Compatibility of Astragalus and Arctium on Glycolipin Metabolism and Renal Lesion in Diabetic Rats |
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| WANG Wei-wei,CHEN Yi-ping.Effects of Compatibility of Astragalus and Arctium on Glycolipin Metabolism and Renal Lesion in Diabetic Rats[J].Chinese Journal of Information on Traditional Chinese Medicine,2008,15(9):31-33. |
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| Authors: | WANG Wei-wei CHEN Yi-ping |
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| Institution: | WANG Wei-wei1,CHEN Yi-ping2 (1.No.455 Hospital of PLA,Shanghai 200052,China,2.Longhua Hospital of Shanghai University of TCM,Shanghai 200032,China) |
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| Abstract: | Objective To investigate the effects of combination of aniso-dosage of Astragalus and Arctium on the glycolipin metabolism and renal lesion in diabetic rats.Method Streptozotocin (STZ)-induced diabetic rats were established as experimental model.The diabetic rats were randomized into model group and mixture-treated group.Astragalus and Arctium were divided into three dosages (low,moderate,high) respectively and combined according to orthogonal experimental design and were administrated to the mixture-treate... |
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| Keywords: | Astragalus Arctium orthogonal design diabetic rats model |
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