Glomerular localization of preformed immune complexes in nephrotoxic serum nephritis |
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| Authors: | S. O'Regan |
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| Affiliation: | (1) Department of Pediatrics (Nephrology Division), University of Montreal, Hôpital Sainte-Justine, Centre de Recherche Pédiatrique, 3175, Chemin Côte Sainte-Catherine, H3T 1C5 Montreal, Quebec, Canada |
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| Abstract: | Summary Pre-formed immune complexes solubilized in antigen excess were infused into rats with nephrotoxic serum nephritis and normal control animals. Complex localization was evident in seven of ten nephrotoxic animals suggesting that the presence of immune mediated glomerular injury makes the kidney susceptibility to further immune injury.Supported by Grant MA-6122, Medical Research Council of Canada |
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| Keywords: | Nephrotoxic nephritis Immune complexes |
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