| 动态浊度法定量测定克林霉素磷酸酯氯化钠注射液中细菌内毒素的含量 |
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| 引用本文： | 王方,宋晓红. 动态浊度法定量测定克林霉素磷酸酯氯化钠注射液中细菌内毒素的含量[J]. 解放军药学学报, 2008, 24(5): 451-453 |
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| 作者姓名： | 王方 宋晓红 |
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| 作者单位： | 解放军第153中心医院,药剂科,河南,郑州,450042 |
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| 摘 要： | 目的探讨建立动态浊度法定量测定克林霉素磷酸酯氯化钠注射液中细菌内毒素的方法。方法参照中国药典2005年版附录中细菌内毒素检查法及细菌内毒素检查法应用指导原则的规定，对克林霉素磷酸酯氯化钠注射液中细菌内毒素定量测定进行可行性研究。结果克林霉素磷酸酯氯化钠注射液经8倍稀释后可完全消除其对鲎试剂与细菌内毒素凝集反应的干扰。结论应用动态浊度法定量测定克林霉素磷酸酯氯化钠注射液中细菌内毒素含量，结果准确，在实际应用中完全可行。
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| 关 键 词： | 克林霉素磷酸酯氯化钠注射液 动态浊度法 细菌内毒素 |
Quantitative Detection of Bacterial Endotoxin in Clindmycin Phosphate Sodium Chloride Injection by Kinetic Turbidimetric Assay |
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| WANG Fang,SONG Xiao-Hong. Quantitative Detection of Bacterial Endotoxin in Clindmycin Phosphate Sodium Chloride Injection by Kinetic Turbidimetric Assay[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2008, 24(5): 451-453 |
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| Authors: | WANG Fang SONG Xiao-Hong |
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| Affiliation: | (Department of Pharmacy, Hospital 153 of PLA, Zhengzhou 450042, Henan China) |
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| Abstract: | Aim To establish a quantitative method for detecting bacterial endotoxin in Clindmycin phosphate sodium chloride injection through kinetic turbidimetric assay.Methods A study was performed of the feasibility of quantitative detection of bacterial endotoxin in Clindmycin phosphate sodium chloride injection,based on the appendix of China Pharmacopoeia 2005.Results Diluting the Clindmycin phosphate sodium chloride injection for 8 times can completely eliminate its interference with the TAL preparations.Conclusion Quantitative detection of bacterial endotoxin in Clindmycin phosphate sodium chloride injection by kinetic turbidimetric assay is entirely feasible in practice. |
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| Keywords: | Clindmycin phosphate sodium chloride injection Kinetic turbidimetric assay Bacterial endotoxin |
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