经颅彩色多普勒超声诊断脑动脉狭窄与闭塞的应用价值

目的：探讨经颅彩色多普勒超声（transcranial color-coded duplex sonography, TCCS）对脑动脉狭窄与闭塞的诊断价值。方法：对临床上怀疑有脑血管疾病的70例患者行TCCS和数字减影血管造影（DSA）检查，以DSA作为金标准，两者进行比较分析。结果：TCCS诊断脑动脉狭窄与闭塞的真实性指标灵敏度、特异度、假阳性率、假阴性率、准确度、阳性预测值、阴性预测值、阳性似然比、阴性似然比、约登指数分别为75.0%，81.6%，18.4%，25.0%，78.6%，77.4%，79.5%，4.1，0.3，0.57；可靠性指标符合率为78.6%、卡帕值为0.57。结论：TCCS具有一定的诊断真实性与可靠性，可作为脑动脉狭窄与闭塞的早期筛检性诊断方法。

Application value of transcranial color-coded duplex sonography in the diagnosis of cerebral artery stenosis or occlusion

Objective: The aim of this study was to evaluate diagnostic value of transcranial color-coded duplex sonography(TCCS) on the cerebral artery stenosis or occlusion. Methods: Seventy patients suspected of cerebrovascular disease were examined by TCCS. The results were compared with digital subtract angiography(DSA), which was the gold standard. Results: The validity index, including the sensitivity, specificity, false positive rate, false negative rate, accuracy, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and Youden's index, were 75.0%, 81.6%, 18.4%, 25.0%, 78.6%, 77.4%, 79.5%, 4.1, 0.3 and 0. 57 respectively. The agreement rate and Kappa value were 78.6% and 0.57. Conclusions: TCCS was reliable in the diagnosis of cerebral artery stenosis or occlusion. It could be chosen as a method of screening diagnosis.