阿托伐他汀强化调脂对不稳定型心绞痛的疗效及血清高敏C反应蛋白的影响

目的 观察阿托伐他汀强化调脂对不稳定型心绞痛患者的疗效及血清超敏C反应蛋白( hs-CRP)的影响.方法 纳入不稳定型心绞痛患者60例,随机分为常规治疗组(基础治疗+阿托伐他汀10 mg/d),他汀强化治疗组(基础治疗+阿托伐他汀40 mg/d).疗程均为8周.观察、对比治疗前后血清hs-CRP、血脂变化、心电图疗效及硝酸甘油停减情况.结果 两组心绞痛疗效及血清hs-CRP水平差异均有统计学意义(均P ＜0.05).结论 短期他汀类强化调脂治疗不稳定型心绞痛安全有效,可以迅速改善血管内高炎症状态,进而防止不稳定斑块的破裂、血栓形成,从而防止心血管事件的发生.

The curative effect of intensive regulating lipid by atorvastatin in the treatment of unstable angina and its influence on serum hs-CRP

Objective To observe the curative effect of intensive regulating lipid by atorvastatin in the treatment of unstable angina and its influence on serum high sensitive C-reactive protein（hs-CRP）.Methods 60 patients with unstable angina were randomly divided into two groups：the routine treatment group（basic treatment plus atorvastatin 10mg/d）,the atorvastatin intensive treatment group（basic treatment plus atorvastatin 40mg/d.）The courses of treatment were both 8 weeks. The differences in the amount of serum hs-CRP, blood fat,the effect of electrocardiogram and the use of glyceryl trinitrate before and after the treatment were observed and compared.Results The differences in the angina curative effect and the amount of serum hs-CRP between the two groups were statistically significant（all P＜0.05）.Conclusion Short-term intensive regulating lipid by statins was effective in treating unstable angina,and could quickly relieve the phlogosis in the vessels, prevent the unstable plaque from breaking and the thrombopoiesis,and thus prevent the occurrence of cardiovascular disease.