冠心病患者血清D-二聚体和纤维蛋白原检测的意义

目的 探讨冠心病患者血清D-二聚体(D-D)和纤维蛋白原(Fg)检测的意义.方法 150例冠心病患者随机分为不稳定型心绞痛组(UA组)、稳定型心绞痛组(SA组)和急性心肌梗死组(AMI组)各50例,采用ELASA双抗夹心法检测D-D水平,CLAUSE法检测Fg水平.结果 SA组D-D水平与UA组、AMI组差异均有统计学意义(t=9.340、18.334,均P＜0.01);UA组D-D水平与AMI组差异有统计学意义(t=10.240,P＜0.01).SA组Fg水平与UA组、AMI组差异均有统计学意义(t=11.376、11.730,均P＜0.01);UA组Fg水平与AMI组差异有统计学意义(t=3.121,P＜0.01).D-D水平:单支病变组与双支病变组、三支病变组差异均有统计学意义(t=7.017、15.603,均P＜0.01);双支病变组与三支病变组差异有统计学意义(t =8.662,P＜0.01).Fg水平:单支病变组与双支病变组、三支病变组差异均有统计学意义(t=8.687、11.855,均P＜0.01);双支病变组与三支病变组差异有统计学意义(t=4.379,P＜0.01).结论 不同类型冠心病患者血清D-D、Fg水平有较大差异,且冠状动脉病变越严重,D-D和Fg水平越高.

The detection meaning of D-dimer and fibrinogen in patients with coronary disease

Objective To explore the detection meaning of D-dimer（D-D） and fibrinogen（Fg） in patients with coronary disease. Methods 150 patients with coronary disease were randomly divided into UA group,SA group and AMI group,the D-D was detected by ELASA double resistance to clip method and Fg was detected by CLIUSE methods. Results The D-D in SA group, UA group and AMI group showed significant difference between two groups （SA：UA,t =9. 340;SA：AMI,t = 18. 334; UA：AMI,t = 10. 240. all P 〈0. O1 ）. The Fg in SA group,UA group and AMI group showed significant difference between each two groups （ SA ： UA, t = 11. 376 ; SA ： AMI, t = 11. 730 ; UA ： AMI, t = 3. 121. all P 〈 O. O1 ）. D-D between one coronary artery disease and two coronaries artery disease, three coro- nary arteries disease showed significant difference（ t = 7. 017,15. 603, all P 〈 0.01 ） ; and between two coronaries ar- tery disease and three coronary arteries disease showed significant difference, too（ t = 8. 662, P 〈 0. O1 ）. The Fg be- tween one coronary artery disease and two coronaries artery disease, three coronary arteries disease, showed significant difference（ t = 8. 687,11. 855, all P 〈 O. O1 ）;and between two coronaries artery disease and three coronary arteries disease showed significant difference, too （ t = 4. 379,P 〈 O. O1 ）. Conclusion The D-D and Fg showed obvious difference between different types of coronary disease, and the levels increase along with the disease degrees of coronaries artery.