纳洛酮与脑蛋白水解物联合治疗新生儿缺氧缺血性脑病

目的 探讨治疗中重度新生儿缺氧缺血性脑病(HIE)的有效方法.方法 选择中重度HIE患儿46例,并随机分为两组.对照组21例仅采用HIE常规治疗,治疗组25例在常规治疗基础上给予脑蛋白水解物联合纳洛酮治疗,比较两组疗效与临床指标.结果 治疗组显效率、总有效率均显著高于对照组(均P＜0.01),意识恢复时间、原始能力恢复时间、惊厥时间、肌张力恢复时间、吸吮能力恢复时间、住院时间均显著低于对照组(P＜0.05或P＜0.01).结论 纳洛酮与脑蛋白水解物联合治疗中重度HIE疗效显著.

Clinical observation of naloxone for the treatment of neonatal hypoxic-ischemic encephalopathy

Objective To explore effective treatment for moderate and severe neonatal hypoxic-ischemic encephalopathy（HIE）.Methods 46 cases of moderate to severe HIE were randomly divided into two groups.Control group of 21 cases only accepted the HIE conventional treatment,treatment group,25 cases accepted the HIE conventional treatment and were also given brain protein hydrolyzate combined naloxone treatment,the efficacy of various clinical indicators of the two groups were compared.Results The remarkable effective rate and the total effective rate of the treatment group were significantly higher（all P＜0.01）.Consciousness recovery time,recovery time of the original ability,convulsions,muscle tension,recovery time,sucking ability,recovery time,hospital days of treatment group were significantly lower than the control group（P＜0.05 or P＜0.01）.Conclusion The effect of naloxone therapy for moderate to severe HIE is significant,and the therapy has high clinical value.