依达拉奉对血管性痴呆患者认知功能的影响

目的 观察依达拉奉对血管性痴呆患者认知功能的影响.方法 70例轻中度血管性痴呆患者随机分为观察组(采用依达拉奉治疗)和对照组(采用吡拉西坦治疗)各35例,疗程为2周,采用简易精神状态检查(MMSE)、画钟试验(CDT)和蒙特利尔认知评估量表(MoCA)评估两组认知功能.结果 观察组治疗后MMSE、CDT、MoCA评分与治疗前差异均有统计学意义(t=4.21、1.45、12.37,均P＜0.05),对照组治疗后与治疗前差异均无统计学意义(均P＞0.05).结论 依达拉奉通过清除自由基,抗氧化损伤,能够改善血管性痴呆患者的认知功能.

The influence of edaravone on cognitive ability in patients with vascular dementia

Objective To observe the influence of edaravone on the cognitive ability in patients with vascular dementia（VD）. Methods 70 cases with mild to moderate VD were randomly divided into observation group （edara- vone treatment）and control group（ piracetam treatment） ,35 cases in each group. Treatment cycle was two weeks. The scores of MMSE,CDT, MoCA were compared before and after treatment between the two groups. Results The scores were found to be significantly higher after use edaravone in the observation group （ t = 4. 21,1.45,12.37, all P 〈 0. 05 ）. The score had no difference before and after treatment in the control group （ P 〉 0. 05 ）. Conclusion Edara- vone could improve cognitive abilitys in VD patients through its function of anti-oxidant and free-radical scavenging.