受体酪氨酸激酶EphA2与喉癌血管生成的关系

目的 探讨受体酪氨酸激酶EphA2在喉鳞状细胞癌组织中的表达与肿瘤血管生成的关系.方法 采用免疫组化S-P法检测EphA2和CD34在20例正常鳞状上皮组织和50例喉鳞状细胞癌组织中的表达,并分析EphA2表达强度与微血管密度(MVD)的关系.结果 EphA2和CD34在血管内皮细胞的胞膜和胞浆内表达.在正常鳞状上皮组织中CD34标记的MVD值为(17.15±5.21),而在喉鳞状细胞癌组织中为(54.89±13.67)；EphA2在喉鳞状细胞癌组织中的平均表达计分为(4.56±1.38),而在正常鳞状上皮中为(2.49±1.23),两组差异均有统计学意义(t=16.721,5.847,均P＜0.05).EphA2在喉鳞状细胞癌中的表达强度与MVD计数呈直线正相关关系(P＜0.01).结论 EphA2可能与喉癌血管生成有关,抑制EphA2表达可抑制肿瘤血管生长,从而抑制肿瘤生长.

Relationship between EphA2 and Laryngeal Carcinoma Angiogenesis

Objective To study the relationship between EphA2 and laryngeal carcinoma angionegesis.Methods Immunohistochemical staining was used to determine the expression of EphA2 and CD34 in 20 normal squamous epithelium tissues and 50 laryngeal carcinoma.The relationship between EphA2 expression and Microvascular density was analyzed bg Spearman correlation and linear regression.Results The MVD in laryngeal carcinoma（54.89±13.67） was significantly higher than that in normal squamous epithelial tissues（17.15±5.21）;The EphA2 in laryngeal carcinoma（4.56±1.38） was significantly higher than that in normal squamous epithelial tissues（2.49±1.23）（t=16.721,5.847,all P＜0.05）.There was significant positive linear correlation between EphA2 and MVD in laryngeal squamous cell carcinoma（P＜0.01）.Conclusion EphA2 may correlate with angionegesis in laryngeal squamous cell carcinoma.