初发急性脑梗死卒中部位、严重程度与卒中后抑郁的相关性分析

目的 探讨初发急性脑梗死(ACI)患者卒中部位、严重程度与卒中后抑郁(PSD)的相关性.方法 对100例初发ACI患者通过CT或MRI进行病灶定位,于发病后第2周采用汉密尔顿抑郁量表、美国国立卫生研究院卒中量表指数进行评分.结果 初发ACI大脑半球左、右侧病灶、多发病灶患者间PSD发生率差异无统计学意义(23.91％、25.00％、33.33％,x2=0.2512,P＞0.05),前循环梗死与后循环梗死PSD发生率差异有统计学意义(33.96％、14.89％,x2=4.8307,P＜0.05)；卒中严重程度与PSD发生率呈正相关(16.67％、31.37％、36.36％,x2=3.9188,P＜0.05).结论 初发ACI患者PSD的发生与卒中部位无明显相关性,且前循环梗死和神经功能缺损严重者PSD的发生率高.

The analysis of the correlation between lesion location of the first onset acute cerebral infarction, stroke severity and post-stroke depression

Objective To explore the relationship between lesion location of the first onset acute cerebral infarction（ ACI ） , stroke severity and post-stroke depression （PSD）. Methods The lesion locations of ACI were ob- served by CT or MRI. 100 patients with the first onset ACI were assessed by Hamilton Depression Scale and the Na- tional Institutes of Health Stroke Scale two weeks after stroke. Results There was no significant difference in the in- cidence of PSD among the patients with left, right and bilateral lesions in acute stroke（23.91% ,25.00% ,33.33% , X2 = 0. 2512 ,P 〉 0.05 ）. The incidence of PSD had significant difference between the anterior-circulation and posteri- or-circulation infarction（33.96%, 14.89%, X2 = 4. 8307, P 〈 0.05 ）. Stroke severity was positively correlated with the incidence of PSD（16.67% ,31.37% ,36.36% ,X2 -3.9188,P 〈0.05）. Conclusion The incidence of PSD was no significant correlation with the stroke site of patients with the first onset ACI ,and the patients with anterior circulation infarction and severe neurological deficit have high incidence of PSD.