Activation of hyaluronidase by 8-methoxypsoralen-polyamine photoproducts. |
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| Authors: | N Shigehara H Kakegawa H Miyataka H Matsumoto A Isobe T Satoh |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. |
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| Abstract: | Ultraviolet radiation of 8-methoxypsoralen (8-MOP) in the presence of various polyamines resulted in stable photoproducts that were very soluble in water and showed hyaluronidase-activating properties. Among them, the photoproducts obtained from the reaction systems of 8-MOP-spermine and 8-MOP-spermidine markedly activated hyaluronidase. The enzyme activity was not affected by 8-MOP alone and the photoproduct of 8-MOP (8-MOP-P). From these facts, it was suggested that the photoproducts with hyaluronidase-activating properties might play an important role in the onset of 8-MOP-induced photosensitivity. |
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