Cholesterol levels in HIV-HCV infected patients treated with lopinavir/r: results from the SCOLTA project. |
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Authors: | Giuseppe Vittorio L De Socio Paolo Bonfanti Elena Ricci Giancarlo Orofino Giordano Madeddu Giovanni Penco Erika Gianelli Canio Martinelli Silvia Carradori Tiziana Quirino Giuliano Rizzardini |
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Institution: | Clinica di Malattie Infettive, Università degli Studi di Perugia, Ospedale Santa Maria della Misericordia, Piazzale Menghini 1, 06129 Perugia, Italy. giuseppedesocio@yahoo.it |
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Abstract: | BACKGROUND: It is not known whether antiretroviral therapy (ART) including lopinavir/r has a different effect on the lipid metabolism in HIV patients co-infected with HCV. This study investigated changes in lipid levels, comparing patients with HIV infection alone and those with HCV too, in the lopinavir/r cohort of the SCOLTA project. METHODS: We analyzed the data for the lopinavir/r nationwide cohort from 25 Italian infectious disease departments, which comprises 743 HIV-infected patients followed prospectively, comparing subjects with HIV-HCV co-infection and those with single-infection. RESULTS: At enrolment, co-infected patients had significantly lower mean cholesterol than HCV negative cases (162+/-43mg/dL vs. 185+/-52mg/dL, p=0.0009). Total and non-HDL cholesterol and triglycerides rose significantly from baseline in HIV single-infection patients, but not in those with co-infection. The patients with dual HIV-HCV infection, treated with an ART regimen including lopinavir/r, have only limited increases in total and non-HDL cholesterol and triglycerides. CONCLUSIONS: Changes in serum lipids in co-infected patients differed significantly from those in patients without HCV. It remains to be seen whether this is associated with a lower risk of progression of atherosclerotic disease. |
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