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| 球旁注射高三尖杉酯碱防治增生性玻璃体视网膜病变的实验研究 | |
| 引用本文： | 龙心光,黄应桂,王映芬,罗晨美.球旁注射高三尖杉酯碱防治增生性玻璃体视网膜病变的实验研究[J].中国中医眼科杂志,2003,13(4):192-194. |
| 作者姓名： | 龙心光 黄应桂 王映芬 罗晨美 |
| 作者单位： | 1. 广东省佛山市中医院眼科,佛山,528000 2. 广东医学院病理学教研室 3. 广东医学院附属医院眼科 |
| 基金项目： | 广东省医学科学技术青年基金课题(B19960 0 71) |
| 摘 要： | 目的 了解球旁注射高三尖杉酯碱对实验性增生性玻璃体视网膜病变 (PVR)的防治效果。方法 兔眼球扁平部切开 8mm ,玻璃体腔内注射自体全血 0 2ml,制作实验性增生性玻璃体视网膜病变模型 ,治疗组每日 1次球旁注射 1mg/ml高三尖杉酯碱注射液 0 5ml,共 7天 ,对照组注射 0 5ml生理盐水。结果 6周后对照组 2 5只兔眼中 2 3只眼 ( 92 % )出现PVR及牵引性视网膜脱离 ,其中 15只眼出现漏斗状全脱离。治疗组 2 8只眼有 11只眼 ( 3 9 3 % )出现PVR及牵引性视网膜脱离 ,其中 2只眼出现漏斗状全脱离。两组比较差异有显著性 (P <0 0 1)。结论 球旁注射高三尖杉酯碱对实验性PVR有一定的防治作用 |
| 关 键 词： | 增生性玻璃体视网膜病变 高三尖杉酯碱 |
| 文章编号： | 1002-4379(2003)04-0192-03 |
An experimental research on treatment of proliferative vitreoretinopathy by peribulbar homoharringtonine injection |
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| LONG Xinguang ,HUANG Yinggui ,WANG Yingfen ,et al.An experimental research on treatment of proliferative vitreoretinopathy by peribulbar homoharringtonine injection[J].Journal of Traditional Chinese Ophthalmology,2003,13(4):192-194. | |
| Authors: | LONG Xinguang HUANG Yinggui WANG Yingfen |
| Institution: | LONG Xinguang 2,HUANG Yinggui 3,WANG Yingfen 4,et al 2 Department of Ophthalmology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China |
| Abstract: | OBJECTIVES To assess therapeutic effect of peribulbar homoharringtonine(HHT)injection on experimental proliferative vitreoretinopathy (PVR) METHODS An experimental model of PVR was induced in rabbits by intravitreous injection of 0 2ml of autologous blood through an 8mm incision at pars plana The rabbits were treated with peribulbar HHT 0 5ml (1mg/ml) injection in the treated group, and NS 0 5ml was injected in the control group once a day for 1 week RESULTS At 6 weeks, PVR occurred in 92% (23 of 25) of the eyes of the control group and traction retinal detachment occurred in 15 eyes of them PVR was 39 3% (11 of 28)and 2 eyes of retinal detachment in the treated group with HHT There was a significant difference between two groups CONCLUSIONS Peribubar HHT injection could decrease the incidence of the traction retinal detachment by PVR in experimental rabbit model |
| Keywords: | proliferative vitreoretinopathy PVR homoharringtonine |
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